LOCUS       NM_003478               6408 bp    mRNA    linear   PRI 04-SEP-2016
DEFINITION  Homo sapiens cullin 5 (CUL5), mRNA.
ACCESSION   NM_003478
VERSION     NM_003478.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6408)
  AUTHORS   Huo Y, Jiang B, Han X and Luo J.
  TITLE     [Cell surface adhesion molecules mediated stretch-induced HL-60
            cell adhesion to mouse common carotid arteries]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30 (8), 802-805 (2014)
   PUBMED   25108430
  REMARK    GeneRIF: Data indicate that cell surface adhesion molecules VCAM-1
            and P-selectin play some roles in mechanical stretch-induced HL-60
            cell adhesion to mouse common carotid arteries.
REFERENCE   2  (bases 1 to 6408)
  AUTHORS   Samant RS, Clarke PA and Workman P.
  TITLE     E3 ubiquitin ligase Cullin-5 modulates multiple molecular and
            cellular responses to heat shock protein 90 inhibition in human
            cancer cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 111 (18), 6834-6839 (2014)
   PUBMED   24760825
  REMARK    GeneRIF: Silencing CUL5 reduced cellular sensitivity to three
            distinct HSP90 inhibitors, across four cancer types driven by
            different protein kinases.
REFERENCE   3  (bases 1 to 6408)
  AUTHORS   Guo Y, Dong L, Qiu X, Wang Y, Zhang B, Liu H, Yu Y, Zang Y, Yang M
            and Huang Z.
  TITLE     Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex
            by HIV-1 Vif
  JOURNAL   Nature 505 (7482), 229-233 (2014)
   PUBMED   24402281
  REMARK    GeneRIF: data reveal the structural basis for Vif hijacking of the
            CBF-beta and CUL5 E3 ligase complex, laying a foundation for
            rational design of novel anti-HIV drugs
REFERENCE   4  (bases 1 to 6408)
  AUTHORS   Wang H, Lv G, Zhou X, Li Z, Liu X, Yu XF and Zhang W.
  TITLE     Requirement of HIV-1 Vif C-terminus for Vif-CBF-beta interaction
            and assembly of CUL5-containing E3 ligase
  JOURNAL   BMC Microbiol. 14, 290 (2014)
   PUBMED   25424878
  REMARK    GeneRIF: These results provide important information on the
            assembly of the Vif-CUL5-E3 ubiquitin ligase and identify a new viV
            binding interface with CBF-beta at the C-terminus of HIV-1 Vif.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6408)
  AUTHORS   Evans SL, Schon A, Gao Q, Han X, Zhou X, Freire E and Yu XF.
  TITLE     HIV-1 Vif N-terminal motif is required for recruitment of Cul5 to
            suppress APOBEC3
  JOURNAL   Retrovirology 11, 4 (2014)
   PUBMED   24422669
  REMARK    GeneRIF: N-terminal mutants of HIV-1 vif that demonstrated reduced
            Cul5 binding were also unable to degrade APOBEC3G as well as
            APOBEC3F.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6408)
  AUTHORS   Burnatowska-Hledin M, Lazdins IB, Listenberger L, Zhao P,
            Sharangpani A, Folta V and Card B.
  TITLE     VACM-1 receptor is specifically expressed in rabbit vascular
            endothelium and renal collecting tubule
  JOURNAL   Am. J. Physiol. 276 (2 PT 2), F199-F209 (1999)
   PUBMED   9950950
REFERENCE   7  (bases 1 to 6408)
  AUTHORS   North WG, Fay MJ, Longo KA and Du J.
  TITLE     Expression of all known vasopressin receptor subtypes by small cell
            tumors implies a multifaceted role for this neuropeptide
  JOURNAL   Cancer Res. 58 (9), 1866-1871 (1998)
   PUBMED   9581826
REFERENCE   8  (bases 1 to 6408)
  AUTHORS   Stankovic T, Byrd PJ, Cooper PR, McConville CM, Munroe DJ, Riley
            JH, Watts GD, Ambrose H, McGuire G, Smith AD, Sutcliffe A, Mills T
            and Taylor AM.
  TITLE     Construction of a transcription map around the gene for ataxia
            telangiectasia: identification of at least four novel genes
  JOURNAL   Genomics 40 (2), 267-276 (1997)
   PUBMED   9119394
REFERENCE   9  (bases 1 to 6408)
  AUTHORS   Byrd,P.J., Stankovic,T., McConville,C.M., Smith,A.D., Cooper,P.R.
            and Taylor,A.M.
  TITLE     Identification and analysis of expression of human VACM-1, a cullin
            gene family member located on chromosome 11q22-23
  JOURNAL   Genome Res. 7 (1), 71-75 (1997)
   PUBMED   9037604
REFERENCE   10 (bases 1 to 6408)
  AUTHORS   Kipreos ET, Lander LE, Wing JP, He WW and Hedgecock EM.
  TITLE     cul-1 is required for cell cycle exit in C. elegans and identifies
            a novel gene family
  JOURNAL   Cell 85 (6), 829-839 (1996)
   PUBMED   8681378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA099369.1, AA471067.1, AK125294.1, BC063306.1, BC017838.1,
            BC037203.1, H01402.1 and AA403092.1.
            [WARNING] On Jan 19, 2017 this sequence was replaced by
            NM_003478.4.
            On Jun 11, 2005 this sequence version replaced NM_003478.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063306.1, AK292575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AA099369.1         1-11
            12-51               AA471067.1         1-40
            52-237              AK125294.1         1-186
            238-496             BC063306.1         1-259
            497-891             AK125294.1         446-840
            892-997             BC017838.1         237-342
            998-4835            BC063306.1         761-4598
            4836-5164           BC037203.1         1222-1550
            5165-5180           H01402.1           122-137             c
            5181-5387           BC063306.1         4942-5148
            5388-5467           AA403092.1         1-80                c
            5468-5478           BC063306.1         5229-5239
            5479-6408           BC037203.1         1865-2794
FEATURES             Location/Qualifiers
     source          1..6408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..6408
                     /gene="CUL5"
                     /gene_synonym="VACM-1; VACM1"
                     /note="cullin 5"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
     misc_feature    473..475
                     /gene="CUL5"
                     /gene_synonym="VACM-1; VACM1"
                     /note="upstream in-frame stop codon"
     CDS             668..3010
                     /gene="CUL5"
                     /gene_synonym="VACM-1; VACM1"
                     /note="Cullin-5 (vasopressin-activated calcium-mobilizing
                     receptor-1); Vasopressin-activated calcium-mobilizing
                     receptor-1; CUL-5; vasopressin-activated
                     calcium-mobilizing receptor 1"
                     /codon_start=1
                     /product="cullin-5"
                     /protein_id="NP_003469.2"
                     /db_xref="CCDS:CCDS31668.1"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
                     /translation="MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLF
                     SDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFT
                     QCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAM
                     KLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQA
                     PSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKET
                     ILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETIT
                     TDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQK
                     GVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVF
                     MRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQ
                     AFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNH
                     SGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATE
                     LPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQK
                     RGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVE
                     ILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA"
     misc_feature    767..769
                     /gene="CUL5"
                     /gene_synonym="VACM-1; VACM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q93034.4);
                     phosphorylation site"
     misc_feature    1295..1297
                     /gene="CUL5"
                     /gene_synonym="VACM-1; VACM1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:18669648};
                     propagated from UniProtKB/Swiss-Prot (Q93034.4);
                     phosphorylation site"
ORIGIN      
        1 gcagtcaaca catatttact gggcgcattc tatgcacgag ttattgaaga cagctgttgt
       61 aagcatttca ggacaatgca cctcccttaa caccgagtcc gggatttggg gcggggtgcc
      121 ggaaaacgcc aggtcccgcc agcagagggc acggtcccgg cctcgctgca gcctcgggac
      181 ccaccgaggc ttccaggctc ccacgctcgc tcccgagcgc gtccccgccc tcgcgtcacg
      241 tgacgtggcc gcggaacctg agctgcgggg cctaagccga gctaaattcg ttgcaggtgg
      301 ccgcggcggg tgcaaccaca aaggctaatc cgaaggagtc ggggaggctc gtggagtcga
      361 tgcttcctct tccaagtcag gtcggctccc gttaccttct cagcattcgc cgttccggtc
      421 ttcctgagcg cgtgcatgag gtctttcgcg tggggaagct ccggtgacca tgtaggggac
      481 aagagtgagg aagctcctgg tgcttgggac gaggtcagcg ctgtcggcgc gctgctccag
      541 cgcccaccac accctggtgc gggccgacgg gccctgggcc ctggtgggag ctccggcctc
      601 cggtcaaggc ctggccggga gcgccacgaa ttctcgcgtc gtctcgcgag agtccaagtt
      661 aaagaacatg gcgacgtcta atctgttaaa gaataaaggt tctcttcagt ttgaagacaa
      721 atgggatttt atgcgcccga ttgttttgaa gcttttacgc caggaatctg ttacaaaaca
      781 gcagtggttt gatctgtttt cggatgtgca tgcagtctgt ctttgggatg ataaaggccc
      841 agcaaaaatt catcaggctt taaaagaaga tattcttgag tttattaagc aagcacaggc
      901 acgagtactg agccatcaag atgatacggc tttgctaaaa gcatatattg ttgaatggcg
      961 aaagttcttt acacaatgtg atattttacc aaaacctttt tgtcaactag agattacttt
     1021 aatgggtaaa cagggcagca ataaaaaatc aaatgtggaa gacagtattg ttcgaaagct
     1081 tatgcttgat acatggaatg agtcaatctt ttcaaacata aaaaacagac tccaagatag
     1141 tgcaatgaag ctggtacatg ctgagagatt gggagaagct tttgattctc agctggttat
     1201 tggagtaaga gaatcctatg ttaacctttg ttctaatcct gaggataaac ttcaaattta
     1261 tagggacaat tttgagaagg catacttgga ttcaacagag agattttata gaacacaagc
     1321 accctcgtat ttacaacaaa atggtgtaca gaattatatg aaatatgcag atgctaaatt
     1381 aaaagaagaa gaaaaacgag cactacgtta tttagaaaca agacgagaat gtaactccgt
     1441 tgaagcactc atggaatgct gtgtaaatgc cctggtgaca tcatttaaag agactatctt
     1501 agctgagtgc caaggcatga tcaagagaaa tgaaactgaa aaattacatt taatgttttc
     1561 attgatggac aaagttccta atggtataga gccaatgttg aaagacttgg aggaacatat
     1621 cattagtgct ggcctggcag atatggtagc agctgctgaa actattacta ctgactctga
     1681 gaaatacgtt gagcagttac ttacactatt taatagattt agtaaactcg tcaaagaagc
     1741 ttttcaagat gatccacgat ttcttactgc aagagataag gcgtataaag cagttgttaa
     1801 tgatgctacc atatttaaac ttgaattacc tttgaagcag aagggggtgg gattaaaaac
     1861 tcagcctgaa tcaaaatgcc ctgagctgct tgccaattac tgtgacatgt tgctaagaaa
     1921 aacaccatta agcaaaaaac taacctctga agagattgaa gcaaagctta aagaagtgct
     1981 cttggtactt aagtatgtac agaacaaaga tgtttttatg aggtatcata aagctcattt
     2041 gacacgacgt cttatattag acatctctgc cgatagtgaa attgaagaaa acatggtaga
     2101 gtggctaaga gaagttggta tgccagcgga ttatgtaaac aagcttgcta gaatgtttca
     2161 ggacataaaa gtatctgaag atttgaacca agcttttaag gaaatgcaca aaaataataa
     2221 attggcatta ccagctgatt cagttaatat aaaaattctg aatgctggcg cctggtcaag
     2281 aagttctgag aaagtctttg tctcacttcc tactgaactg gaggacttga taccggaagt
     2341 agaagaattc tacaaaaaaa atcatagtgg tagaaaatta cattggcatc atctcatgtc
     2401 aaatggaatt ataacattta agaatgaagt tggtcaatat gatttggagg taaccacgtt
     2461 tcagctcgct gtattgtttg catggaacca aagacccaga gagaaaatca gctttgaaaa
     2521 tcttaagctt gcaactgaac tccctgatgc tgaacttagg aggactttat ggtctttagt
     2581 agctttccca aaactcaaac ggcaagtttt gttgtatgaa cctcaagtca actcacccaa
     2641 agactttaca gaaggtaccc tcttctcagt gaaccaggag ttcagtttaa taaaaaatgc
     2701 aaaggttcag aaaaggggta aaatcaactt gattggacgt ttgcagctca ctacagaaag
     2761 gatgagagaa gaagagaatg aaggaatagt tcaactacga atactaagaa cccaggaagc
     2821 tatcatacaa ataatgaaaa tgagaaagaa aattagtaat gctcagctgc agactgaatt
     2881 agtagaaatt ttgaaaaaca tgttcttgcc acaaaagaaa atgataaaag agcaaataga
     2941 gtggctaata gagcacaaat acatcagaag agatgaatct gatatcaaca ctttcatata
     3001 tatggcataa ttttgaatat catggacaat atttagaacc caaattttgg agtgcttggg
     3061 cagaaagttg taaagtttgt gctggagaaa ggtttatttg gactttgatt acataaatat
     3121 taaaatctct gccttacctt acaaaaacaa ctatattttg ccaatcacat tagttagcat
     3181 gatggcattc ccttcatgtt gcacactctt tgacagcatg ctgttttgtg gagaaacttg
     3241 cattcatgaa gagcccatta tcaactttta aaagtgaatt tgatttgtac ccaccaggag
     3301 aaatacagtt gggaagggtg agggtggggt tcttgttgct tttttctctt ttttcctctc
     3361 ttaaaaaatg tacttgcaca aggaaggatc ttcagatatt catgcactga aaaatgctgt
     3421 tatcttttgt ttttaaaaaa tgcaattaaa actagaaata gcactcttgg tttcttttga
     3481 tgaaaagagt gagctggtca atgcaacatt gggaaacggc agatgtaggt gagaagttaa
     3541 gtatttaata gtatcaaatt gttcaaacat tgctcagtat aataactgga ttttaatggt
     3601 gacctaaaaa tggtattaaa tattttcaac tttcaaatgt tggttttctt taagcaggag
     3661 actgctattt tagttgttgt taaatgatga ggagtttttt tttttttaaa tatggctgga
     3721 aagcttgttt tgaaaaatga agcttatatt aattgttgct tcaatagttt aaaaaattta
     3781 tggagatagg taggtcatta tgattgcaga gccaaaatag caaaacaaac atattaagtg
     3841 tgtttactaa acatattgtg tgtttactaa cacacttaat gtttatatac ctaatattta
     3901 ttatgccata tctgaattta ttaaaaacaa cacagaaatc tcctgctctg atatagttat
     3961 gtaactgatc tcttaatctg tagcatagaa gtattttggt attttaaggt ctcatgatta
     4021 gggatttgta gcctcaggtt tgaatcagtc acctaggggt aagagaaaaa ccacaacata
     4081 agacctgaaa aacagaagca aaattgttgc actcttaata cgagcagtaa acttgccaaa
     4141 tatatgtaca tatatattta tatattttaa aaataaacat tttttaaatc gtcagaaggc
     4201 aacatttacc atgttccttt cagtctatcc aaagtagcaa cttaactagt tgctggcaac
     4261 tgaataccca gagtagtgga aattttagga cttgaggacg tgaacaactt gaaagagaaa
     4321 attgattccc cttgaggaaa gaatggctca acgtggattt ttattcattg tggtgcacgt
     4381 ttcaaatttt cttgcaaatt attttatatc ttatttgatg ttaagtaata tttttaaagt
     4441 atggtttttg aagatagtag gaaatggagt acagaaaggc atacagtatt atgttacagt
     4501 ggagtgcttt caagagcatt tcgtaggatc tgtccccatc cgaagaggct ttgtgaactg
     4561 cctgctgaat ggaaggaaag caactttaaa acatttagag ttttgctgag tatagccaaa
     4621 tgcctgttct gaaacttata ggaaattgga attttgttta aaattttaca ctttaaggta
     4681 gcaaatgtca attattagac cgagcatatt gtgaagaatt aaactaaaat taatacgtac
     4741 agttttctct aattaggtga ctgttcataa tgggtatatt tggaatttag aagaaataat
     4801 tttgtagtaa ttgtggccct tatgtttaac agataattca gcattggcgt atttgcttgt
     4861 cccaatacaa gaatgccaaa ggaggaaaca ggaaaaattg ccgtccattt taaaaattta
     4921 ggtttgttgt tttaaaccat aattgttctc agaacttttt tggaacttct aattttgggt
     4981 catttaattt aagaatgaga gtcatgatgt tttgatttat gaaggtgaat ttaatgcaaa
     5041 agtgggtaac actacattca tagcaaagtt ttttattaaa ttttataaat ttttaatagc
     5101 caattatgtc ctaattgtat tttggggaat gaacagcagc aaatactgta aatgtacagt
     5161 tttctttttt tttttttttt ggttatgtat acaaaagttt taactacttt ttggtgttta
     5221 tgaaaatcat ttagttgaca aggtgcctat gccattgtta aattttcttt aagtaattta
     5281 acaacagatt tgctaattta aaaaaaaatg aaaaaaaaaa tcttaccagc agtttgtaaa
     5341 ggtctggaat cacagttggc atcctttatt caggtctctt ctctccagcg tacacttaaa
     5401 attggtgccg agcagggata taacctgcag ttaagtgaaa agaaaatcca gcctccccct
     5461 ccaaaaaaaa aaaaaaaatt taatttttaa aaattagtgg tatggcaata agacacttca
     5521 gaggctatct taacctctga atacccatct tctagtttaa agacagagac atcccatctg
     5581 gaaaatgtta acttgtgttg ccatctcgtt gccggagtaa gtagacataa gacagagttt
     5641 aagaagtaaa aatatagaaa aattttgatg gtcacaatga gataaatatt agaatattac
     5701 tattccaatg attaaatgag gatcttgaaa taaattctga agtcttccaa tttttacatt
     5761 tattggaggg gtccctgagt tctgtcaact tttttattta agtctcttgc tcttattttg
     5821 tgcataaatg ttaaaccttc caaaaatgaa atgttagctt tctttctttt actttttatt
     5881 aaatttaata gaaaatatga cctgagtagt taaaaagtat tttgcattat ttgcagtaag
     5941 atgtctctag cactgctcaa agggcaaatt ttaaaacttc agtctgggtg aaagatttgc
     6001 tagttttaca gaaagatttg ctatcttaaa ctcaagctgg tttttctgtt ctcatgtaag
     6061 tgactgggat gctgtcttat gaattcttcc aaggtcatgt ttgtgaaata aacattacat
     6121 gagagctttc ctgtcatcta cactatatgt tgtctggagt gttgaacaaa tttattttag
     6181 tttctaagtt gtaatctatc ctcatatggt ctatacgatt ttgaatgtgt gccactacat
     6241 actgagatga taatgctgta caattttaag tggtagcagt ttctgtatgc agtaggctga
     6301 aatattttga tgaactgctt aatttttgga ttttattttt taagttgtat aatttatttt
     6361 cttgcaaaat aaaaatgtaa tataaaaaaa aataaaaaaa aaaaaaaa
//

