LOCUS       KY565180                1728 bp    RNA     linear   VRL 01-MAR-2018
DEFINITION  Hepatitis C virus isolate 1a138_s29_v16 polyprotein gene, partial
            cds.
ACCESSION   KY565180
VERSION     KY565180.1
KEYWORDS    .
SOURCE      Hepacivirus C
  ORGANISM  Hepacivirus C
            Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
            Amarillovirales; Flaviviridae; Hepacivirus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   El-Diwany,R., Cohen,V.J., Mankowski,M.C., Wasilewski,L.N.,
            Brady,J.K., Snider,A.E., Osburn,W.O., Murrell,B., Ray,S.C. and
            Bailey,J.R.
  TITLE     Extra-epitopic hepatitis C virus polymorphisms confer resistance to
            broadly neutralizing antibodies by modulating binding to scavenger
            receptor B1
  JOURNAL   PLoS Pathog. 13 (2), E1006235 (2017)
   PUBMED   28235087
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   El-Diwany,R., Cohen,V.J., Mankowski,M.C., Wasilewski,L.N.,
            Brady,J.K., Snider,A.E., Osburn,W.O., Murrell,B., Ray,S.C. and
            Bailey,J.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-FEB-2017) Medicine, Johns Hopkins University, 855 N.
            Wolfe Street, Suite 530, Baltimore, MD 21205, USA
COMMENT     ##Assembly-Data-START##
            Sequencing Technology :: Sanger dideoxy sequencing
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Hepacivirus C"
                     /mol_type="genomic RNA"
                     /isolate="1a138_s29_v16"
                     /isolation_source="plasma"
                     /host="Homo sapiens"
                     /db_xref="taxon:11103"
                     /country="USA"
     CDS             <1..>1728
                     /note="E1E2 region"
                     /codon_start=1
                     /product="polyprotein"
                     /protein_id="AQV09117.1"
                     /translation="GCSFSIFLLALLSCLTVPASAYQVRNSTGLYHVTNDCPNSSIVY
                     EAADAILHTPGCVPCVREGNASRCWVAVTPTVATRDGKLPTTQLRRHIDLLVGSATLC
                     SALYVGDLCGSVFLVGQLFTFSPRRHWTTQGCNCSIYPGHITGHRMAWDMMMNWSPTA
                     ALVVAQLLRIPQAILDMIAGAHWGVLAGMAYFSMVGNWAKVLVVLLLFAGVDAETHVS
                     GGTAARATARLANFFSPGAMQNIQLVNTNGSWHINRTALNCNDSLNTGWVAGLFYHYK
                     FNSSGCPERLASCRRLNDFAQGWGPIRYANGSGPDQRPYCWHYPPKPCGFVPAKSVCG
                     PVYCFTPSPVVVGTTDKLGAPTFSWGENDTDVFVLNNTRPPLGNWFGCTWMNSTGFTK
                     VCGAPPCAIGGVGNNTLLCPTDCFRKHPEATYSRCGSGPWITPRCLVDYPYRLWHYPC
                     TINYTIFKVRMYAGGVEHRLDAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCS
                     FTTLPALSTGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADARVCSCLW
                     MMLLISQAEA"
ORIGIN      
        1 ggttgctctt tctctatctt ccttctggct ctgctctctt gtctcactgt gcccgcttca
       61 gcctaccaag tgcgcaactc cacggggctc taccatgtca ccaatgattg ccctaactcg
      121 agtattgtgt acgaggcggc tgatgccatt ctgcacactc cggggtgcgt cccttgtgtt
      181 cgcgagggta acgcctcgag gtgttgggtg gcagtgaccc ccacggtggc caccagggac
      241 ggcaaactcc ccacaacgca gcttcgacgt cacatcgatc tgcttgtcgg gagcgctacc
      301 ctctgctcgg ccctctacgt gggggacctg tgcgggtctg tctttcttgt cggtcagctg
      361 tttaccttct ctcccaggcg ccactggacg acgcaaggct gtaattgttc catctatccc
      421 ggccatataa cgggtcaccg catggcgtgg gatatgatga tgaactggtc ccctacggcg
      481 gcgttggtag tagctcagct gctccggatc ccacaagcca tcttggacat gatcgctggt
      541 gctcactggg gagtcctggc gggcatggcg tatttctcca tggtggggaa ctgggcgaag
      601 gtcctggtag tgctgctgct atttgccggc gtcgacgcgg aaacccacgt ctccggggga
      661 actgcagccc gcgccacagc tagacttgcc aatttcttct caccgggcgc catgcagaac
      721 atccagctgg tcaacactaa cggtagttgg cacattaatc gcacagccct gaactgcaat
      781 gatagcctta acaccggctg ggtagcgggg ctcttctacc actacaaatt caactcctcg
      841 ggctgtcccg agaggttggc cagctgccgg cgcctcaacg actttgccca aggctggggc
      901 cctattaggt atgccaacgg aagcggcccc gaccaacggc cctattgctg gcactacccc
      961 ccaaaacctt gtgggtttgt gcccgcaaag agcgtgtgtg gcccggtata ttgcttcact
     1021 cccagtcctg tggtggtggg aacgaccgac aagttgggcg cgcctacctt cagctggggt
     1081 gagaatgata cggacgtctt cgtccttaac aacactaggc caccgctggg caattggttc
     1141 ggttgcacct ggatgaactc aaccggattc accaaagtgt gcggagcgcc cccttgtgcc
     1201 atcggagggg tgggcaacaa caccttgctt tgccccactg attgtttccg caagcatccg
     1261 gaagccacgt actctcggtg cggctccggt ccctggatta cacccaggtg cctggttgac
     1321 tacccgtata ggctttggca ttatccttgt accatcaact acaccatatt taaagtcagg
     1381 atgtacgcgg gaggggtcga gcacaggctg gacgctgcct gcaactggac gcggggcgag
     1441 cgttgtgatc tggaagacag agacaggtcc gagctcagcc cgctgctgct gtccaccaca
     1501 cagtggcagg tccttccatg ctcttttacg accctgccag ccctgtccac cggccttatc
     1561 cacctccacc agaacatcgt ggacgtgcag tacttgtacg gggtggggtc aagcatcgcg
     1621 tcttgggcca ttaagtggga gtacgtcgtt ctcctgttcc tcctgcttgc agacgcgcgc
     1681 gtctgctcct gcttgtggat gatgttactc atatcccaag cggaggcg
//

