LOCUS       KJ187983                1705 bp    RNA     linear   VRL 09-APR-2014
DEFINITION  Hepatitis C virus subtype 1a isolate H77_w7 polyprotein gene,
            partial cds.
ACCESSION   KJ187983
VERSION     KJ187983.1
KEYWORDS    .
SOURCE      Hepatitis C virus subtype 1a
  ORGANISM  Hepatitis C virus subtype 1a
            Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
            Amarillovirales; Flaviviridae; Hepacivirus.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Osburn,W.O., Snider,A.E., Wells,B.L., Latanich,R., Bailey,J.R.,
            Thomas,D.L., Cox,A.L. and Ray,S.C.
  TITLE     Clearance of Hepatitis C infection is associated with early
            appearance of broad neutralizing antibody responses
  JOURNAL   Hepatology (2014) In press
   PUBMED   24425349
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Osburn,W.O., Snider,A.E., Wells,B.L., Latanich,R., Bailey,J.R.,
            Thomas,D.L., Cox,A.L. and Ray,S.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2014) Ctr for Viral Hepatitis Research, Div of
            Infectious Diseases, Dept of Med, Johns Hopkins Medical
            Institutions, 855 N. Wolfe St, suite 530, Baltimore, MD 21205, USA
COMMENT     ##Assembly-Data-START##
            Sequencing Technology :: Sanger dideoxy sequencing
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Hepatitis C virus subtype 1a"
                     /mol_type="genomic RNA"
                     /isolate="H77_w7"
                     /isolation_source="obtained at 49 days after HCV
                     infection"
                     /host="Homo sapiens"
                     /db_xref="taxon:31646"
                     /clone="4-1-1"
                     /country="USA"
     CDS             <1..>1705
                     /note="E1E2 region"
                     /codon_start=2
                     /product="polyprotein"
                     /protein_id="AHV90289.1"
                     /translation="LALLSCLTVPASAYQVRNSSGLYHVTNDCPNSSIVYEAADAILH
                     TPGCVPCVREGNASRCWVAVTPTVATRDGKLPTTQLRRHIDLLVGSATLCSALYVGDL
                     CGSVFLVGQLFTFSPRRHWTTQDCNCSIYPGHITGHRMAWDMMMNWSPTAALVVAQLL
                     RIPQAIMDMIAGAHWGVLAGIAYFSMVGNWAKVLVVLLLFAGVDAETHVTGGNAGRTT
                     AGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFNSSGCPE
                     RLASCRRLTDFAQGWGPISYANGSGLDERPYCWHYPPRPCGIVPAKSVCGPVYCFTPS
                     PVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCV
                     IGGVGNNTLLCPTDCFRKHPEATYSRCGSGPWITPRCMVNYPYRLWHYPCTINYTIFK
                     VRMYVGGVEHRLEAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTLPALS
                     TGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADARVCSCLWMMLLISQA
                     EA"
     mat_peptide     65..640
                     /product="E1"
     mat_peptide     641..1705
                     /product="E2"
ORIGIN      
        1 tctggccctg ctctcttgcc tgactgtgcc cgcttcagcc taccaagtgc gcaattcctc
       61 ggggctttac catgtcacca atgattgccc taactcgagt attgtgtacg aggcggccga
      121 tgccatcctg cacactccgg ggtgtgtccc ttgcgttcgc gagggtaacg cctcgaggtg
      181 ttgggtggcg gtgaccccca cggtggccac cagggacggc aaactcccca caacgcagct
      241 ccgacgtcat atcgatctgc ttgtcgggag cgccaccctc tgctcggccc tctacgtggg
      301 ggacctgtgc gggtctgtct ttcttgttgg tcaactgttt accttctctc ccaggcgcca
      361 ctggacgaca caagactgca attgttctat ctatcctggc catataacgg gtcatcgcat
      421 ggcatgggat atgatgatga actggtcccc tacggcagcg ttggtggtag ctcagctgct
      481 ccggatccca caagccatca tggacatgat cgctggtgct cactggggag tcctggcggg
      541 catagcgtat ttctccatgg tggggaactg ggcgaaggtc ctggtagtgc tgctgctatt
      601 tgccggcgtc gacgcggaaa cccacgtcac cgggggaaat gccggccgca ccacggctgg
      661 gcttgttggt ctccttacac caggcgccaa gcagaacatc caactgatca acaccaacgg
      721 cagttggcac atcaatagca cggccttgaa ctgcaatgaa agccttaaca ccggctggtt
      781 agcagggctc ttctatcagc acaaattcaa ctcttcaggc tgtcctgaga ggttggccag
      841 ctgccgacgc cttaccgatt ttgcccaggg ctggggtcct atcagttatg ccaacggaag
      901 cggcctcgac gaacgcccct actgctggca ctaccctcca agaccttgtg gcattgtgcc
      961 cgcaaagagc gtgtgtggcc cggtatattg cttcactccc agccccgtgg tggtgggaac
     1021 gaccgacagg tcgggcgcgc ctacctacag ctggggtgca aatgatacgg atgtcttcgt
     1081 ccttaacaac accaggccac cgctgggcaa ttggttcggt tgtacctgga tgaactcaac
     1141 tggattcacc aaagtgtgcg gagcgccccc ttgtgtcatc ggaggggtgg gcaacaacac
     1201 cttgctctgc cccactgatt gtttccgcaa gcatccggaa gccacatact ctcggtgcgg
     1261 ctccggtccc tggattacac ccaggtgcat ggtcaactac ccgtataggc tttggcacta
     1321 tccttgtacc atcaattaca ccatattcaa agtcaggatg tacgtgggag gggtcgagca
     1381 caggctggaa gcggcctgca actggacgcg gggcgaacgc tgtgatctgg aagacaggga
     1441 caggtccgag ctcagcccat tgctgctgtc caccacgcag tggcaggtcc ttccgtgttc
     1501 tttcacgacc ctgccagcct tgtccaccgg cctcatccac ctccaccaga acattgtgga
     1561 cgtgcagtac ttgtacgggg tagggtcaag catcgcgtcc tgggccatta agtgggagta
     1621 cgtcgttctc ctgttcctcc tgcttgcaga cgcgcgcgtc tgctcctgct tgtggatgat
     1681 gttactcata tcccaagcgg aggcg
//

