LOCUS       KY565210                1728 bp    RNA     linear   VRL 01-MAR-2018
DEFINITION  Hepatitis C virus isolate 1b025_2212 polyprotein gene, partial cds.
ACCESSION   KY565210
VERSION     KY565210.1
KEYWORDS    .
SOURCE      Hepacivirus C
  ORGANISM  Hepacivirus C
            Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
            Amarillovirales; Flaviviridae; Hepacivirus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   El-Diwany,R., Cohen,V.J., Mankowski,M.C., Wasilewski,L.N.,
            Brady,J.K., Snider,A.E., Osburn,W.O., Murrell,B., Ray,S.C. and
            Bailey,J.R.
  TITLE     Extra-epitopic hepatitis C virus polymorphisms confer resistance to
            broadly neutralizing antibodies by modulating binding to scavenger
            receptor B1
  JOURNAL   PLoS Pathog. 13 (2), E1006235 (2017)
   PUBMED   28235087
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   El-Diwany,R., Cohen,V.J., Mankowski,M.C., Wasilewski,L.N.,
            Brady,J.K., Snider,A.E., Osburn,W.O., Murrell,B., Ray,S.C. and
            Bailey,J.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-FEB-2017) Medicine, Johns Hopkins University, 855 N.
            Wolfe Street, Suite 530, Baltimore, MD 21205, USA
COMMENT     ##Assembly-Data-START##
            Sequencing Technology :: Sanger dideoxy sequencing
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Hepacivirus C"
                     /mol_type="genomic RNA"
                     /isolate="1b025_2212"
                     /isolation_source="plasma"
                     /host="Homo sapiens"
                     /db_xref="taxon:11103"
                     /country="USA"
     CDS             <1..>1728
                     /note="E1E2 region"
                     /codon_start=1
                     /product="polyprotein"
                     /protein_id="AQV09147.1"
                     /translation="GCSFSIFLLALLSCLTIPASAIEVRNVSGVYHVTNDCSNASIVY
                     EAADVIMHTPGCVPCVREGNSSRCWVALTPTLAARNSSIPTTTIRRHVDLLVGTAAFC
                     SAMYVGDLCGSVFLVSQLFTFSPRRHETVQDCNCSIYPGHVSGHRMAWDMMMNWSPTT
                     ALVVSQLLRIPQAVVDVVVGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGETYTT
                     GGAQARNVRTFTSLFTAGPSQKIQLINTNGSWHINRTALNCNDSLNTGFLAALFYVQR
                     FNASGCPERMASCRPIDKFAQGWGPITYVKPAISDQKPYCWHYAPQPCGIVPASQVCG
                     PVYCFTPSPVVVGTTDRFGVPTYNWGENETDVLLLNNTRPPQGNWFGCTWMNGTGFTK
                     TCGGPPCNIGGAGNDTLTCPTDCFRKHPEATYTKCGSGPWLTPRCMVDYPYRLWHYPC
                     TVNFTIFKVRMYVGGVEHRLTAACNWTRGERCDLEDRDRSELSPLLLSTTEWQVLPCS
                     FTTLPALSTGLIHLHRNIVDVQYLYGIGSAVVSYAIKWEYVLLLFLFLADARVCACLW
                     MMLLIAQAEA"
ORIGIN      
        1 ggttgctctt tctctatctt cctcttggct ttgctgtcct gtttgaccat cccagcttcc
       61 gctatcgaag tgcgcaacgt gtccggagtg taccatgtca cgaacgactg ctccaacgca
      121 agtattgtgt atgaggcagc ggacgtgatc atgcataccc ccgggtgcgt gccctgcgtc
      181 cgggagggca actcctcccg ctgctgggta gcgctcactc ccacgctcgc ggccaggaac
      241 tccagcatcc ccactacgac aatacgacgc cacgtcgatt tgctcgttgg gacggctgct
      301 ttttgctccg ctatgtacgt gggagatctt tgcggatctg ttttccttgt ctctcagctg
      361 ttcaccttct cgcctcgccg gcatgagaca gtacaggact gcaattgttc aatctatccc
      421 ggccacgtat ctggtcaccg catggcttgg gacatgatga tgaactggtc acctacaaca
      481 gctctagtgg tgtcgcagtt actccggatc ccacaagccg tcgtggacgt ggtggtggga
      541 gcccactggg gagtcctggc gggcctcgcc tactactcca tggtggggaa ctgggctaag
      601 gttttgattg tgatgctact ttttgccggt gtcgatggag agacttacac gacggggggg
      661 gcgcaggccc gtaacgtccg cacgtttacg agcctcttca cggctgggcc atcccaaaaa
      721 atccagctta taaacaccaa cggcagttgg cacatcaaca ggactgccct gaactgcaat
      781 gactccctca acaccgggtt ccttgccgcg ctgttctacg tccagagatt caacgcgtcc
      841 ggatgcccag agcgcatggc cagctgccgc cccattgaca aattcgctca ggggtggggt
      901 cccatcactt atgttaagcc ggccatctcg gaccagaagc cctattgttg gcactacgca
      961 ccccaaccgt gcggtattgt acccgcgtcg caggtgtgcg gtccagtgta ctgtttcacc
     1021 ccaagccctg ttgtggtggg gacgaccgat cgtttcggcg tccctacata taactggggg
     1081 gagaatgaga cggacgtgct gcttctcaac aacacgcggc cgccacaggg caactggttc
     1141 ggctgcacat ggatgaatgg cactgggttc accaagacgt gcgggggccc cccgtgcaac
     1201 atcggggggg ccggtaatga caccttgacc tgccccacgg attgcttccg gaagcacccc
     1261 gaggccactt acaccaaatg cggttcgggg ccctggctga cgcctagatg catggttgac
     1321 tacccataca ggctttggca ttacccctgc actgtcaatt ttaccatctt caaggttagg
     1381 atgtatgtgg ggggtgtgga acacaggctc accgccgcat gcaactggac ccgaggagag
     1441 cgttgtgact tggaggacag ggatagatca gagcttagcc cgctgctgct gtctacaaca
     1501 gagtggcagg tgttgccctg ttccttcacc accctaccgg ctttgtccac cggcttgatc
     1561 catctccacc ggaacatcgt ggacgtgcaa tacctgtacg gtatagggtc agcggttgtc
     1621 tcctacgcaa ttaagtggga gtatgtcctg ttgctcttcc ttttcctggc ggacgcgcgc
     1681 gtctgtgcct gcttgtggat gatgctgcta atagctcagg ctgaggcc
//

