LOCUS       KJ187987                1705 bp    RNA     linear   VRL 09-APR-2014
DEFINITION  Hepatitis C virus subtype 1b isolate 11_v07 polyprotein gene,
            partial cds.
ACCESSION   KJ187987
VERSION     KJ187987.1
KEYWORDS    .
SOURCE      Hepatitis C virus subtype 1b
  ORGANISM  Hepatitis C virus subtype 1b
            Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
            Amarillovirales; Flaviviridae; Hepacivirus.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Osburn,W.O., Snider,A.E., Wells,B.L., Latanich,R., Bailey,J.R.,
            Thomas,D.L., Cox,A.L. and Ray,S.C.
  TITLE     Clearance of Hepatitis C infection is associated with early
            appearance of broad neutralizing antibody responses
  JOURNAL   Hepatology (2014) In press
   PUBMED   24425349
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Osburn,W.O., Snider,A.E., Wells,B.L., Latanich,R., Bailey,J.R.,
            Thomas,D.L., Cox,A.L. and Ray,S.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2014) Ctr for Viral Hepatitis Research, Div of
            Infectious Diseases, Dept of Med, Johns Hopkins Medical
            Institutions, 855 N. Wolfe St, suite 530, Baltimore, MD 21205, USA
COMMENT     ##Assembly-Data-START##
            Sequencing Technology :: Sanger dideoxy sequencing
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Hepatitis C virus subtype 1b"
                     /mol_type="genomic RNA"
                     /isolate="11_v07"
                     /isolation_source="obtained at 284 days after HCV
                     infection"
                     /host="Homo sapiens"
                     /db_xref="taxon:31647"
                     /clone="5-1-1"
                     /country="USA"
     CDS             <1..>1705
                     /note="E1E2 region"
                     /codon_start=2
                     /product="polyprotein"
                     /protein_id="AHV90293.1"
                     /translation="LALLSCLTIPASAYEVRNVSGVYHVTNDCSNSSIVYEAADMIMH
                     TPGCVPCVRENNSSRCWVALTPTLAARNASVPTTTIRRHVDLLVGAAAFCSAMYVGDL
                     CGSVFLVSQLFTFSPRRHETVQDCNCSIYPGHVTGHRMAWDMMMNWSPASALVVSQLL
                     RIPQAVVDMVAGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGATHTIGGTQGRNT
                     YGLTTLFSPGSSQRIQLVNTNGSWHINRTALNCNDSLNTGFLAALFYVNKFNASGCPE
                     RMASCRPIDEFDQGWGPITHAGPRSSDQRPYCWHYAPQPCGIVPAAQVCGPVYCFTPS
                     PVVVGTTDQFGAPTYNWGENETDVLLLNNTRPPLGNWFGCTWMNSSGFTKTCGGPPCN
                     IGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVHYPYRLWHYPCTVNFTIFK
                     VRMYVGGVEHRLEAACNWTRGERCNLEDRDRSELSPLLLSTTEWQVLPCSFTTLPALS
                     TGLIHLHQNIVDVQYLYGIGSVVVSFAIRWEYVLLLFLLLADARICACLWMMLLIAQA
                     EA"
     mat_peptide     65..640
                     /product="E1"
     mat_peptide     641..1705
                     /product="E2"
ORIGIN      
        1 cttggctctg ctgtcctgtc tgaccatccc agcttccgct tatgaagtgc gcaacgtgtc
       61 cggagtgtac catgtcacga acgactgctc caactcaagc attgtgtatg aggcagcgga
      121 catgatcatg catacccccg ggtgcgtgcc ctgcgttcgg gagaacaact cctcccgctg
      181 ctgggtagcg ctcactccca cgctcgcggc caggaacgcc agcgtcccca ctacgacgat
      241 acgacgccac gtcgatttgc tcgttggggc ggctgccttc tgctccgcta tgtatgtggg
      301 agatctctgc ggatccgtct tcctcgtctc ccagctgttc accttctcac ctcgccggca
      361 tgagacagtg caggactgca attgctcaat ctaccctggc cacgtgacag gtcatcgcat
      421 ggcttgggat atgatgatga actggtcacc tgcatcagcc ctagtggtat cacagttact
      481 ccggatccca caagctgtcg tggatatggt ggcgggggcc cactggggag tcctggcggg
      541 ccttgcctac tactccatgg tggggaactg ggctaaggtg ttaattgtga tgctactctt
      601 tgccggcgtt gatggggcga cccatacgat aggggggacg cagggccgta acacctacgg
      661 gctcacgacc ctcttttcac ctggttcgtc ccagaggatc cagcttgtaa acaccaacgg
      721 cagctggcac atcaacagga ctgccctgaa ctgcaatgac tccctcaaca ctgggttcct
      781 tgccgcgctg ttctatgtaa acaagttcaa tgcgtcagga tgcccagagc gcatggccag
      841 ctgccgcccc attgacgagt tcgatcaggg gtggggtccc atcactcacg ctgggccgcg
      901 cagctcggac cagaggcctt actgttggca ctacgcgcct caaccgtgcg gtatcgtacc
      961 cgcggcgcag gtgtgtggtc cagtgtattg cttcactcca agccctgtcg tggtggggac
     1021 gaccgaccag ttcggcgccc ctacgtacaa ttggggggag aatgagacgg acgtgctgct
     1081 tctcaacaac acgcggccgc cgctaggcaa ctggttcggc tgtacatgga tgaatagctc
     1141 tgggttcacc aagacgtgcg ggggcccccc gtgcaatatc gggggggtcg gcaataacac
     1201 cttgacctgc cccacggact gcttccggaa gcaccccgag gccacttaca ccaaatgcgg
     1261 ttcggggcca tggttaacac ctagatgttt ggtccactac ccatacaggc tctggcacta
     1321 cccctgcact gtcaacttta ccatcttcaa ggttaggatg tatgtagggg gtgtggagca
     1381 caggctcgaa gccgcatgca attggactcg aggggagcgt tgcaacttgg aggacaggga
     1441 tagatcagag cttagcccgc tgctgctgtc tacaacagag tggcaggtat tgccctgttc
     1501 cttcaccacc ttaccagctc tatccaccgg cctgattcat ctccaccaga acatcgtgga
     1561 cgtgcaatac ctgtacggta tagggtcggt ggttgtctcc tttgcaatca gatgggagta
     1621 tgtcctgttg ctcttcctcc tcctggcgga cgcgcgcatc tgtgcctgct tatggatgat
     1681 gctgctgata gctcaagctg aggcc
//

