LOCUS pHnS_2comp_Donor;smFP-V5_KO;Template_ORF0 5593 bp DNA circular UNA 11-JUL-2025 DEFINITION . ACCESSION urn.local...17-jebled8 VERSION urn.local...17-jebled8 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers misc_feature 1..130 /standard_name="ITR" source 169..1501 /mol_type="other DNA" /organism="synthetic DNA construct" misc_feature 172..190 /standard_name="Primer site #1" misc_feature 191..480 /standard_name="bU6" misc_feature 481..500 /standard_name="gRNA #1" misc_feature 483..488 /standard_name="BbsI" misc_feature 501..594 /standard_name="Scaffold cr1" misc_feature 563..574 /standard_name="T-lock" misc_feature 595..601 /standard_name="polyT" misc_feature 602..621 /standard_name="Primer site #2" regulatory 622..934 /note="Geneious type: promoter" /note="RNA polymerase III promoter for mouse U6 snRNA (Das et al., 1988)" /standard_name="mU6 promoter" primer_bind 853..873 /standard_name="mU6-F" primer_bind complement(914..935) /standard_name="SEQ_mU6_last_R" misc_feature 936..955 /standard_name="gRNA #2" misc_feature 956..1051 /standard_name="Scaffold cr2" misc_feature 1018..1029 /standard_name="T-lock" misc_feature 1052..1058 /standard_name="polyT" misc_feature 1059..1077 /standard_name="Primer site #3" misc_feature 1106..1354 /standard_name="hU6" primer_bind 1106..1126 /standard_name="hU6-F" primer_bind 1277..1296 /standard_name="LKO.1 5'" misc_feature 1355..1374 /standard_name="gRNA #3" misc_feature 1367..1372 /standard_name="BbsI" misc_feature 1375..1391 /standard_name="Scaffold cr3" misc_feature 1396..1470 /standard_name="Scaffold cr3" misc_feature 1437..1448 /standard_name="T-lock" misc_feature 1471..1477 /standard_name="polyT" misc_feature 1478..1499 /standard_name="Primer site #4" misc_feature 1529..1551 /locus_tag="DRSR2" /standard_name="DRSR2" misc_feature 1552..1560 /standard_name="ORF0" source 1561..1605 /chromosome=6 /db_xref="taxon:10090" /map="6 29.15 cM" /mol_type="mRNA" /organism="Mus musculus" /strain="C57BL/6" CDS 1561..1605 /codon_start=1 /transl_table=1 /translation="GGGGSGGGGSGGGGS" /standard_name="Linker" CDS 1612..1653 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" misc_feature 1612..2847 /standard_name="smFP-V5" CDS 1663..1704 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 1714..1755 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" misc_feature 2158..2163 /standard_name="gaagac>gaggat, mutation on BbsI site" CDS 2287..2328 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2338..2379 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2398..2439 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2449..2490 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2704..2745 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2755..2796 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2806..2847 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" primer_bind complement(2838..2859) /standard_name="smV5_R" CDS 2860..2873 /codon_start=1 /locus_tag="X" /transl_table=1 /translation="*LAS" /standard_name="X" misc_feature 2883..2905 /locus_tag="DRSR2(2)" /standard_name="DRSR2+PAM" misc_feature 2953..3082 /standard_name="ITR" rep_origin 3153..3608 regulatory 3634..3738 /note="Geneious type: promoter" /gene="bla" /standard_name="AmpR promoter" CDS join(3739..3807,3808..4599) /codon_start=1 /gene="bla" /note="confers resistance to ampicillin, carbenicillin, and related antibiotics" /product="β-lactamase" /transl_table=1 /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGY IELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVE YSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRL DRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPL LRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIA EIGASLIKHW*" /standard_name="AmpR" rep_origin 4770..5358 ORIGIN 1 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 61 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 121 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctaccg gtaggtccct 181 cgacgttaac cgtgaccgag cttgtctgcc cgcgcagtcc actagacaga cgcgcagagg 241 tcgggcgggc ctagggccaa tttcccatgg ttcccttcat ttgcatatat gatgtaataa 301 ggttatggag actattaaac ttagccctaa tcaaactata tgatgataat gtgtgtggta 361 caaaaggtca taacttatta tatactttga aacttaaaaa agggttacag tttagtcacc 421 ataactgtaa aattttttct attcttagct ttatatagtt cttgagaggc catgtttatg 481 ctgtcttcat catggccgac gtttaagagc tatgctggaa acagcatagc aagtttaaat 541 aaggctagtc cgttatcaac ttggacttcg gtccaagtgg caccgagtcg gtgctttttt 601 tccagtctga ctatcacgat ggatccgacg cgccatctct aggcccgcgc cggccccctc 661 gcacagactt gtgggagaag ctcggctact cccctgcccc ggttaatttg catataatat 721 ttcctagtaa ctatagaggc ttaatgtgcg ataaaagaca gataatctgt tctttttaat 781 actagctaca ttttacatga taggcttgga tttctataag agatacaaat actaaattat 841 tattttaaaa aacagcacaa aaggaaactc accctaactg taaagtaatt gtgtgttttg 901 agactataaa tatcccttgg agaaaagcct tgttggttcg cattatccga accatgtttg 961 agagctatgc agaaagctgc atagcaagtt caaataaggc tagtccgtac acaacttggg 1021 cttcggccta agtggcagcc gagtcggctg ctttttttgc tcgaatctac actcagctat 1081 ggcgcgcccc aaggtcgggc aggaagaggg cctatttccc atgattcctt catatttgca 1141 tatacgatac aaggctgtta gagagataat tggaattaat ttgactgtaa acacaaagat 1201 attagtacaa aatacgtgac gtagaaagta ataatttctt gggtagtttg cagttttaaa 1261 attatgtttt aaaatggact atcatatgct taccgtaact tgaaagtatt tcgatttctt 1321 ggctttatat atcttgtgga aagccagaaa catgtaagcg tcgcaagaag acgggtttca 1381 gagctatgca caagagtgca tagcaagttg aaataaggct agtccgttta caacttggag 1441 cttgctccaa gtggcacccg agtcgggtgc tttttttctc gagtactagg atccattagg 1501 cgccaattct gcagacaaat ggctctaggc gatcgtaatc acccgagtgg gctcgagcaa 1561 ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg gatcgggtcg aggaaaacct 1621 ataccgaacc ccctccttgg acttgatagt actcagcagc agggtaagcc cattccaaac 1681 ccacttctcg gtctggatag cacacagcaa caaggtaagc ctatccctaa ccctctgttg 1741 ggcctggact ccacgggcca aggtgtgagt aagggcgaag aactgtttac cggcgtggtc 1801 ccaattctgg ttgagctcga cggtgacgtt aacggacaca agtttagtgt gcgcggagaa 1861 ggagagggag atgccaccaa cggaaaattg acgctgaagt ttatatgcac cacgggaaag 1921 ctgccggtgc cgtggccgac cttggttaca accctgggtg gcggagtcca gtgtttcagc 1981 cgttacccag accacatgaa gcagcatgac ttctttaaga gtgctatgcc ggagggatac 2041 gtgcaggaac ggacgatcag tttcaaagat gacggtactt acaagacgcg agccgaggtg 2101 aagttcgagg gagacacctt ggtgaacagg atagaactta agggaattga tttcaaggag 2161 gatggtaata ttctgggtca caagctggaa tacaacttta acagccataa cgtctacatt 2221 actgccgaca agcagaagaa cggcataaag gcgaatttca aaattcggca caacgtggaa 2281 ggtggtggca agccgatccc gaatcccctg ctgggcttgg atagcacgca gcaacaggga 2341 aagcccatcc ctaacccctt gctgggactc gacagcaccg gaggccagca aggcggtggc 2401 aaaccgatac ccaatcccct gctcggcctg gatagcaccc agcagcaagg caagccaatc 2461 cccaaccctc tgctgggcct cgactcgaca ggtggcgatg gaagtgttca actggcggac 2521 cactatcagc agaatacgcc gatcggagat ggccccgtgc tgttgccgga taatcactat 2581 ctgtcgactc agagcgttct gagtaaggac ccaaacgaaa aacgagatca catggtgttg 2641 ttggagttcg tgaccgccgc cggcattacg ttgggaatgg acgagctgta caagggccaa 2701 ggaggcaagc ccataccaaa tcccttgctg ggcctcgaca gcactcagca acaaggaaag 2761 ccaataccaa atccactgtt gggcctcgac agtacgcaac agcagggcaa gcccatcccg 2821 aacccgttgc tgggactgga tagtacctaa accggtgctt agctagctag ctaaacggat 2881 ccgcgatcgt aatcacccga gtgggctaga gggggtagat aagtagcatg gcgggttaat 2941 cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc 3001 gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc 3061 agtgagcgag cgagcgcgca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc 3121 ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc 3181 ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc 3241 tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct 3301 aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa 3361 acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc 3421 tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact 3481 caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg 3541 gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct 3601 tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc 3661 taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa 3721 tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt 3781 gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct 3841 gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc 3901 cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta 3961 tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac 4021 tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc 4081 atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac 4141 ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg 4201 gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac 4261 gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc 4321 gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt 4381 gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga 4441 gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc 4501 cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag 4561 atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca 4621 tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc 4681 ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 4741 gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 4801 tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 4861 ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt 4921 ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 4981 gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 5041 ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 5101 tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 5161 ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 5221 agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 5281 agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 5341 gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 5401 tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 5461 accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 5521 gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg 5581 attcattaat gca //