LOCUS pHnS_2comp_Donor;smFP-V5_KO;Gphn#1 5592 bp DNA circular UNA 11-JUL-2025 DEFINITION . ACCESSION urn.local...15-jebled8 VERSION urn.local...15-jebled8 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers misc_feature 1..130 /standard_name="ITR" source 169..1501 /mol_type="other DNA" /organism="synthetic DNA construct" misc_feature 172..190 /standard_name="Primer site #1" misc_feature 191..480 /standard_name="bU6" misc_feature 481..500 /standard_name="gRNA #1" misc_feature 483..488 /standard_name="BbsI" misc_feature 501..594 /standard_name="Scaffold cr1" misc_feature 563..574 /standard_name="T-lock" misc_feature 595..601 /standard_name="polyT" misc_feature 602..621 /standard_name="Primer site #2" regulatory 622..934 /note="Geneious type: promoter" /note="RNA polymerase III promoter for mouse U6 snRNA (Das et al., 1988)" /standard_name="mU6 promoter" primer_bind 853..873 /standard_name="mU6-F" primer_bind complement(914..935) /standard_name="SEQ_mU6_last_R" misc_feature 936..955 /standard_name="gRNA #2" misc_feature 956..1051 /standard_name="Scaffold cr2" misc_feature 1018..1029 /standard_name="T-lock" misc_feature 1052..1058 /standard_name="polyT" misc_feature 1059..1077 /standard_name="Primer site #3" misc_feature 1106..1354 /standard_name="hU6" primer_bind 1106..1126 /standard_name="hU6-F" primer_bind 1277..1296 /standard_name="LKO.1 5'" misc_feature 1355..1374 /standard_name="gRNA #3" misc_feature 1367..1372 /standard_name="BbsI" misc_feature 1375..1391 /standard_name="Scaffold cr3" misc_feature 1396..1470 /standard_name="Scaffold cr3" misc_feature 1437..1448 /standard_name="T-lock" misc_feature 1471..1477 /standard_name="polyT" misc_feature 1478..1499 /standard_name="Primer site #4" misc_feature 1529..1551 /locus_tag="DRSR2" /standard_name="DRSR2" misc_feature 1552..1559 /standard_name="ORF1" source 1560..1604 /chromosome=6 /db_xref="taxon:10090" /map="6 29.15 cM" /mol_type="mRNA" /organism="Mus musculus" /strain="C57BL/6" CDS 1560..1604 /codon_start=1 /transl_table=1 /translation="GGGGSGGGGSGGGGS" /standard_name="Linker" CDS 1611..1652 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" misc_feature 1611..2846 /standard_name="smFP-V5" CDS 1662..1703 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 1713..1754 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" misc_feature 2157..2162 /standard_name="gaagac>gaggat, mutation on BbsI site" CDS 2286..2327 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2337..2378 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2397..2438 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2448..2489 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2703..2744 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2754..2795 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" CDS 2805..2846 /codon_start=1 /product="epitope tag from simian virus 5" /transl_table=1 /translation="GKPIPNPLLGLDST" /standard_name="V5 tag" primer_bind complement(2837..2858) /standard_name="smV5_R" CDS 2859..2872 /codon_start=1 /locus_tag="X" /transl_table=1 /translation="*LAS" /standard_name="X" misc_feature 2882..2904 /locus_tag="DRSR2(2)" /standard_name="DRSR2+PAM" misc_feature 2952..3081 /standard_name="ITR" rep_origin 3152..3607 regulatory 3633..3737 /note="Geneious type: promoter" /gene="bla" /standard_name="AmpR promoter" CDS join(3738..3806,3807..4598) /codon_start=1 /gene="bla" /note="confers resistance to ampicillin, carbenicillin, and related antibiotics" /product="β-lactamase" /transl_table=1 /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGY IELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVE YSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRL DRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPL LRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIA EIGASLIKHW*" /standard_name="AmpR" rep_origin 4769..5357 ORIGIN 1 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 61 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 121 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctaccg gtaggtccct 181 cgacgttaac cgtgaccgag cttgtctgcc cgcgcagtcc actagacaga cgcgcagagg 241 tcgggcgggc ctagggccaa tttcccatgg ttcccttcat ttgcatatat gatgtaataa 301 ggttatggag actattaaac ttagccctaa tcaaactata tgatgataat gtgtgtggta 361 caaaaggtca taacttatta tatactttga aacttaaaaa agggttacag tttagtcacc 421 ataactgtaa aattttttct attcttagct ttatatagtt cttgagaggc catgtttatg 481 agcattgcca gggccatccc gtttaagagc tatgctggaa acagcatagc aagtttaaat 541 aaggctagtc cgttatcaac ttggacttcg gtccaagtgg caccgagtcg gtgctttttt 601 tccagtctga ctatcacgat ggatccgacg cgccatctct aggcccgcgc cggccccctc 661 gcacagactt gtgggagaag ctcggctact cccctgcccc ggttaatttg catataatat 721 ttcctagtaa ctatagaggc ttaatgtgcg ataaaagaca gataatctgt tctttttaat 781 actagctaca ttttacatga taggcttgga tttctataag agatacaaat actaaattat 841 tattttaaaa aacagcacaa aaggaaactc accctaactg taaagtaatt gtgtgttttg 901 agactataaa tatcccttgg agaaaagcct tgttgccaga ctccatcatt tctcggtttg 961 agagctatgc agaaagctgc atagcaagtt caaataaggc tagtccgtac acaacttggg 1021 cttcggccta agtggcagcc gagtcggctg ctttttttgc tcgaatctac actcagctat 1081 ggcgcgcccc aaggtcgggc aggaagaggg cctatttccc atgattcctt catatttgca 1141 tatacgatac aaggctgtta gagagataat tggaattaat ttgactgtaa acacaaagat 1201 attagtacaa aatacgtgac gtagaaagta ataatttctt gggtagtttg cagttttaaa 1261 attatgtttt aaaatggact atcatatgct taccgtaact tgaaagtatt tcgatttctt 1321 ggctttatat atcttgtgga aagccagaaa catgtgctgt agatatcacc aagggtttca 1381 gagctatgca caagagtgca tagcaagttg aaataaggct agtccgttta caacttggag 1441 cttgctccaa gtggcacccg agtcgggtgc tttttttctc gagtactagg atccattagg 1501 cgccaattct gcagacaaat ggctctaggc gatcgtaatc acccgagtgg gctcgagcag 1561 gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgg atcgggtcga ggaaaaccta 1621 taccgaaccc cctccttgga cttgatagta ctcagcagca gggtaagccc attccaaacc 1681 cacttctcgg tctggatagc acacagcaac aaggtaagcc tatccctaac cctctgttgg 1741 gcctggactc cacgggccaa ggtgtgagta agggcgaaga actgtttacc ggcgtggtcc 1801 caattctggt tgagctcgac ggtgacgtta acggacacaa gtttagtgtg cgcggagaag 1861 gagagggaga tgccaccaac ggaaaattga cgctgaagtt tatatgcacc acgggaaagc 1921 tgccggtgcc gtggccgacc ttggttacaa ccctgggtgg cggagtccag tgtttcagcc 1981 gttacccaga ccacatgaag cagcatgact tctttaagag tgctatgccg gagggatacg 2041 tgcaggaacg gacgatcagt ttcaaagatg acggtactta caagacgcga gccgaggtga 2101 agttcgaggg agacaccttg gtgaacagga tagaacttaa gggaattgat ttcaaggagg 2161 atggtaatat tctgggtcac aagctggaat acaactttaa cagccataac gtctacatta 2221 ctgccgacaa gcagaagaac ggcataaagg cgaatttcaa aattcggcac aacgtggaag 2281 gtggtggcaa gccgatcccg aatcccctgc tgggcttgga tagcacgcag caacagggaa 2341 agcccatccc taaccccttg ctgggactcg acagcaccgg aggccagcaa ggcggtggca 2401 aaccgatacc caatcccctg ctcggcctgg atagcaccca gcagcaaggc aagccaatcc 2461 ccaaccctct gctgggcctc gactcgacag gtggcgatgg aagtgttcaa ctggcggacc 2521 actatcagca gaatacgccg atcggagatg gccccgtgct gttgccggat aatcactatc 2581 tgtcgactca gagcgttctg agtaaggacc caaacgaaaa acgagatcac atggtgttgt 2641 tggagttcgt gaccgccgcc ggcattacgt tgggaatgga cgagctgtac aagggccaag 2701 gaggcaagcc cataccaaat cccttgctgg gcctcgacag cactcagcaa caaggaaagc 2761 caataccaaa tccactgttg ggcctcgaca gtacgcaaca gcagggcaag cccatcccga 2821 acccgttgct gggactggat agtacctaaa ccggtgctta gctagctagc taaacggatc 2881 cgcgatcgta atcacccgag tgggctagag ggggtagata agtagcatgg cgggttaatc 2941 attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg 3001 ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca 3061 gtgagcgagc gagcgcgcag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc 3121 caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg 3181 gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct 3241 cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta 3301 aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa 3361 cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct 3421 ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc 3481 aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg 3541 ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt 3601 acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct 3661 aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat 3721 attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg 3781 cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg 3841 aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc 3901 ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat 3961 gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact 4021 attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca 4081 tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact 4141 tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg 4201 atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg 4261 agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg 4321 aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg 4381 caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag 4441 ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc 4501 gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga 4561 tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat 4621 atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc 4681 tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag 4741 accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct 4801 gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac 4861 caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc 4921 tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg 4981 ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt 5041 tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt 5101 gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc 5161 tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca 5221 gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata 5281 gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg 5341 ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct 5401 ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta 5461 ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag 5521 tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga 5581 ttcattaatg ca //