LOCUS Exported 14586 bp ds-DNA circular SYN 23-JUL-2021 DEFINITION Soluble human PACE/furin protease expression. ACCESSION . VERSION . KEYWORDS p1.2-Hyg-Fur SOURCE synthetic DNA construct ORGANISM synthetic DNA construct REFERENCE 1 (bases 1 to 14586) AUTHORS Kovnir SV, Orlova NA, Shakhparonov MI, Skryabin KG, Gabibov AG, Vorobiev II TITLE A Highly Productive CHO Cell Line Secreting Human Blood Clotting Factor IX. JOURNAL Acta Naturae. 2018 Jan-Mar;10(1):51-65. PUBMED 29713519 REFERENCE 2 (bases 1 to 14586) AUTHORS . TITLE Direct Submission JOURNAL Exported Jul 23, 2021 from SnapGene Server 1.1.58 http://www.snapgene.com FEATURES Location/Qualifiers source 1..14586 /organism="synthetic DNA construct" /mol_type="other DNA" primer_bind complement(38..55) /label=L4440 /note="L4440 vector, forward primer" rep_origin complement(209..797) /direction=LEFT /label=ori /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of replication" primer_bind complement(289..308) /label=pBR322ori-F /note="pBR322 origin, forward primer" CDS complement(968..1828) /codon_start=1 /gene="bla" /product="beta-lactamase" /label=AmpR /note="confers resistance to ampicillin, carbenicillin, and related antibiotics" /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYI ELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYS PVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRW EPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSA LPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGAS LIKHW" primer_bind 1591..1610 /label=Amp-R /note="Ampicillin resistance gene, reverse primer" promoter complement(1829..1933) /gene="bla" /label=AmpR promoter regulatory 6471..6480 /regulatory_class="other" /note="vertebrate consensus sequence for strong initiation of translation (Kozak, 1987)" regulatory 7774..7783 /regulatory_class="other" /note="vertebrate consensus sequence for strong initiation of translation (Kozak, 1987)" primer_bind complement(12914..12934) /label=pBABE 3' /note="SV40 enhancer, reverse primer for pBABE vectors" promoter 12919..13248 /label=SV40 promoter /note="SV40 enhancer and early promoter" rep_origin 13099..13234 /label=SV40 ori /note="SV40 origin of replication" primer_bind 13161..13180 /label=SV40pro-F /note="SV40 promoter/origin, forward primer" CDS 13297..14322 /codon_start=1 /gene="aph(4)-Ia" /product="aminoglycoside phosphotransferase from E. coli" /label=HygR /note="confers resistance to hygromycin" /translation="MKKPELTATSVEKFLIEKFDSVSDLMQLSEGEESRAFSFDVGGRG YVLRVNSCADGFYKDRYVYRHFASAALPIPEVLDIGEFSESLTYCISRRAQGVTLQDLP ETELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIADPHVYHWQ TVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLTDNGRITAVIDWSEAMF GDSQYEVANIFFWRPWLACMEQQTRYFERRHPELAGSPRLRAYMLRIGLDQLYQSLVDG NFDDAAWAQGRCDAIVRSGAGTVGRTQIARRSAAVWTDGCVEVLADSGNRRPSTRPRAK E" polyA_signal 14452..14573 /label=SV40 poly(A) signal /note="SV40 polyadenylation signal" primer_bind complement(14489..14508) /label=SV40pA-R /note="SV40 polyA, reverse primer" primer_bind 14543..14562 /label=EBV-rev /note="SV40 polyA terminator, reverse primer" ORIGIN 1 ccgtcgacct ctaggcgcgc catggctctt ccgcttcctc gctcactgac tcgctgcgct 61 cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca 121 cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga 181 accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc 241 acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg 301 cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat 361 acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt 421 atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc 481 agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg 541 acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg 601 gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg 661 gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg 721 gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca 781 gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga 841 acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga 901 tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt 961 ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt 1021 catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat 1081 ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag 1141 caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct 1201 ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt 1261 tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg 1321 cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca 1381 aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt 1441 tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat 1501 gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac 1561 cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa 1621 aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt 1681 tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt 1741 tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa 1801 gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt 1861 atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa 1921 taggggttcc gcgcacattt ccccgaaaag tgccacctgc atctcatcac ggtcacgcat 1981 ggctgcgccc gcgcagcgcc ccccgacccc cccccgatcc ccggaacgcc agccgccatc 2041 caccgcccgc agcccccgga gcccgcggac cccgaccccc cgccgctcgc ccgccgttgc 2101 gccgctctct gcgggggggc tagggggccg cggggggaag gccacgcccc ctccactttt 2161 tccaggaatg cgcggcatga cccgcccccc ccatgacccg ccaacacccc cccgatgccc 2221 cccgggggtc tttcctgggg ggcctttgtc agggttgcct gtgtcaccca cgggcccctt 2281 ggccacgctt gcctgggtca ccccggagcc ccgggtcacg tttgccgggg tcagccctgg 2341 ggcgcttctt cacgctccat tgccatgcag aattcactag tgattagaat cccacgttgt 2401 gcatagaaac agatgcaggc aaaacatcca cacatataaa acaaaaaatt aaaaccaata 2461 aaactcctaa acttttggtc tttcttgaat cttcaatccc tcaggttatg aaataatcat 2521 ttatgcagtc aaaaatttgc cattcttgtt gccaggtgtg gtgatgattc ggggaagcag 2581 aagcaggcag atctctgtga atgaggccag cctggtctac aaagtgagtc ccaggacagt 2641 caggcctgtt acacagagaa accttgaaaa aaaaaagata atatgtactg ttgtattacc 2701 ccaatatata aggctaaacc attagaagca caacactgtt aagtacggaa aataatatct 2761 agtgtggtac agttactact actataatac actaatatag ctgtgggaaa ctagttccaa 2821 agatgaatta ctaaccagtg tttccaagga aataaatgaa agcagagaga ttagttctat 2881 tgctagtgtt tcattttcgt atatttctta caatttctct tgttacaaat aggcactagg 2941 gtatcaagat aattttaacg actggctgag aaccctagaa aatctctgtg aaaaagggat 3001 ttgtgaaatg agagagggta atgtggccat tatagaaaag gcttttgtgt gccttgcatg 3061 catagaccct gtgtttgatc tcttaacacc ctccttgacc agaaaaagct tctgtggata 3121 gaaaatgatt agttatatat acttttaggg aaacgtagtt ctggattctt tggttacaat 3181 taacagaatt aagtgcaaac aaagccagaa acctcctgat aaatgagaaa acctgcttgt 3241 agaaggttgt aaggctctgt aatataggaa ttaggagaaa agaaacctgt gtggtggggc 3301 acgtctgtaa tcccagcatt gggaagtaga ggtagaagat tagaaatcaa aggccagcct 3361 cagcaacaca gtgagtttga ggccaccctg aactacatca ggttctgtct cctttctttt 3421 tttttttttt cttttctttt tttggtttct ctgtgtagtt ttggagccta tcctggcact 3481 agctctgaag agcaggctgg cctcgaactc agagatcagc cagcctctgc tgggattaaa 3541 ggtatgcacc accaacgccc caggttttgt ctcaaacaaa caaaaataac atcaggaggt 3601 ggtgagaggg ctcagtggtc acaggcattc tctgcaaagc ctgactctga gttggatcct 3661 ttagagctac atggttgagg gaagagaact gactcctgga aggtgtcctc tggtccccac 3721 acatagctat acacagcatg tgcattcaca cacactaaat aatgctattt ttaaaaaaat 3781 taaaaacaac aacagtttgg gttgtgaaaa ctagaactag ataataggta agaatcaagt 3841 atcatgtaaa tttgctttca actcatccca aaatttgttt tatatttcag tttttttcct 3901 tcctagcttg actgtggagt cttgtccgga agcaaatagt tcctttgcag atcccacatg 3961 tggacaccgg acagtaggtc ctcaaatgct ccttattagg ttggttcaat aatatcaatt 4021 gtttgttact aggcagtgat gttgtacatc tggaggagat ctcttgagcc cataatcagg 4081 ttattaggaa taaatactct aaggctaaaa atgtagctta gtgataagag tgcttgcctg 4141 gtgtgctgag accctcggtt ccatctccac aaccccatat tccattacaa aatacctttt 4201 caccgtccct agcattaaga aacaaaacaa caaagaagtt tttctttctt ctgagatcct 4261 gcccggagag gcatttaaaa ctggccaggg ccaaaaaaaa aaaaaaaaga aaaaaaagaa 4321 aagaaaacag gctagggccg gcatggtggc gcacgccttt aatcccagca cgcaggaggc 4381 agaggcaggg cggatctctg tgagtttgag gtcagcctgg tctacctagt gagtttcagg 4441 gcacccaggg ctaaagagac tgtctcaaaa acaaaacagc cacacaatca gaaccacagc 4501 aaaacgcagt tatgatcctt ggaactgtag gaatgacaag catttaaata ataggacgag 4561 ccatttttga gaagctctga tttcacaagt gtcagggatg ggctctgggc gagtaagatt 4621 gctaatgctg gcctctaaat gagaccacgt ggagttgatt agattctttt catgttcctc 4681 gtgctctatc aaataactgt acccaaatac acacacacac acacacacac aatgcgcgca 4741 cacacaaaat ccttttttag cttaagaagc ccagaatcag aagtaaagct aactgtggga 4801 cttaagtatt attctgaacg gaactcccag ggcgtgaagc gcgcttcagg cttccagaga 4861 agcagctggc gctggatgga atgaaccaag aggccagcac aggggcagat ccgtcgagct 4921 ctcggccacc gagctgagcc cttaggttct ggggctggga agggtcccta ggattgtgca 4981 cctctcccgc gggggacaag cagggggatg gcggggctga cgtcgggagg tggcctccac 5041 gggaagggac acccggatct cgacacagcc ttggcagtgg agtcaggaag ggtagggaca 5101 gattctggac gccctcttgg ccagctcctc accgccccac ccccgactgg agccgagagt 5161 aattcataca aaaggaggga tcgccttcgc ccctgggaat cccagggacc gtcgctaaat 5221 tctggccggc ctcccagccc ggaaccgctg tgcccgccca gcgcggcggg aggagcctgc 5281 gcctagggcg gatcgcgggt cggcgggaga gcacaagccc acagtccccg gcggtggggg 5341 aggggcgcgc tgagcggggg cccgggagcc agcgcggggc aaactgggaa agtggcgtcg 5401 tgtgctggct ccgccctctt cccgagggtg ggggagaacg gtataaaagt gcggtagtcg 5461 cgttggacgt tctttttcgc aacgggtttg ccgtcagaac gcaggtgagt ggcgggtgtg 5521 gcctccgcgg gcccgggctc cctcctttga gcggggtcgg gccgccgtgc gggtgtcgtc 5581 ggccgggctt ctctgcgagc gttcccgccc tggatggcgg gctgtgcggg agggcgaggg 5641 ggggaggcct ggcggcggcc ccggagcctc gcctcgtgtc gggcgtgagg cctagcgtgg 5701 cttccgcccc gccgcgtgcc accgcggccg cgctttgctg tctgcccggc tgccctcgat 5761 tgcctgcccg cggcccgggc caacaaaggg agggcgtgga gctggctggt agggagcccc 5821 gtagtccgca tgtcgggcag ggagagcggc agcagtcggg ggggggaccg ggcccgcccg 5881 tcccgcagca catgtccaac gccgcctgga cgggtagcgg cctgtgtcct gataaggcgg 5941 ccgggcggtg ggttttagat gccgggttca ggtggccccg ggtcccggcc cggtctggcc 6001 agtaccccgt agtggcttag ctccgaggag ggcgaggccc gcccgcccgg caccagttgc 6061 gtgcgcggaa agatggccgc tcccgggccc tgtagcaagg agctcaaaat ggaggacgcg 6121 gcagcccggc ggagcggggc gggtgagtca cccacacaaa ggaagagggc cttgcccctc 6181 gccggccgct gcttcctgtg accccgtggt gtaccggccg cacttcagtc accccgggcg 6241 ctctttcgga gcaccgctgg cctccgctgg gggaggggat ctgtctaatg gcgttggagt 6301 ttgctcacat ttggtgggtg gagactgtag ccaggccagc ctggccatga aagtaattct 6361 tggaatttgc ccattttgag tttggagcga agctgattga caaagctgct tagccgttca 6421 aaggtattct tcgaactttt tttttaaggt gttgtgaaaa cctcgaggcc gccaccatgg 6481 agctgaggcc ctggttgcta tgggtggtag cagcaacagg aaccttggtc ctgctagcag 6541 ctgatgctca gggccagaag gtcttcacca acacgtgggc tgtgcgcatc cctggaggcc 6601 cagcggtggc caacagtgtg gcacggaagc atgggttcct caacctgggc cagatcttcg 6661 gggactatta ccacttctgg catcgaggag tgacgaagcg gtccctgtcg cctcaccgcc 6721 cgcggcacag ccggctccag agggagcctc aagtacagtg gctggaacag caggtggcaa 6781 agcgacggac taaacgggac gtgtaccagg agcccacaga ccccaagttt cctcagcagt 6841 ggtacctgtc tggtgtcact cagcgggacc tgaatgtgaa ggcggcctgg gcgcagggct 6901 acacagggca cggcattgtg gtctccattc tggacgatgg catcgagaag aaccacccgg 6961 acttggcagg caattatgat cctggggcca gttttgatgt caatgaccag gaccctgacc 7021 cccagcctcg gtacacacag atgaatgaca acaggcacgg cacacggtgt gcgggggaag 7081 tggctgcggt ggccaacaac ggtgtctgtg gtgtaggtgt ggcctacaac gcccgcattg 7141 gaggggtgcg catgctggat ggcgaggtga cagatgcagt ggaggcacgc tcgctgggcc 7201 tgaaccccaa ccacatccac atctacagtg ccagctgggg ccccgaggat gacggcaaga 7261 cagtggatgg gccagcccgc ctcgccgagg aggccttctt ccgtggggtt agccagggcc 7321 gaggggggct gggctccatc tttgtctggg cctcggggaa cgggggccgg gaacatgaca 7381 gctgcaactg cgacggctac accaacagta tctacacgct gtccatcagc agcgccacgc 7441 agtttggcaa cgtgccgtgg tacagcgagg cctgctcgtc cacactggcc acgacctaca 7501 gcagtggcaa ccagaatgag aagcagatcg tgacgactga cttgcggcag aagtgcacgg 7561 agtctcacac gggcacctca gcctctgccc ccttagcagc cggcatcatt gctctcaccc 7621 tggaggccaa taagaacctc acatggcggg acatgcaaca cctggtggta cagacctcga 7681 agccagccca cctcaatgcc aacgactggg ccaccaatgg tgtgggccgg aaagtgagcc 7741 actcatatgg ctacgggctt ttggacgcag gtgccatggt ggccctggcc cagaattgga 7801 ccacagtggc cccccagcgg aagtgcatca tcgacatcct caccgagccc aaagacatcg 7861 ggaaacggct cgaggtgcgg aagaccgtga ccgcgtgcct gggcgagccc aaccacatca 7921 ctcggctgga gcacgctcag gcgcggctca ccctgtccta taatcgccgt ggcgacctgg 7981 ccatccacct ggtcagcccc atgggcaccc gctccaccct gctggcagcc aggccacatg 8041 actactccgc agatgggttt aatgactggg ccttcatgac aactcattcc tgggatgagg 8101 atccctctgg cgagtgggtc ctagagattg aaaacaccag cgaagccaac aactatggga 8161 cgctgaccaa gttcaccctc gtactctatg gcaccgcccc tgaggggctg cccgtacctc 8221 cagaaagcag tggctgcaag accctcacgt ccagtcaggc ctgtgtggtg tgcgaggaag 8281 gcttctccct gcaccagaag agctgtgtcc agcactgccc tccaggcttc gccccccaag 8341 tcctcgatac gcactatagc accgagaatg acgtggagac catccgggcc agcgtctgcg 8401 ccccctgcca cgcctcatgt gccacatgcc aggggccggc cctgacagac tgcctcagct 8461 gccccagcca cgcctccttg gaccctgtgg agcagacttg ctcccggcaa agccagagca 8521 gccgagagtc cccgccacag cagcagccac ctcggctgcc cccggaggtg gaggcggggc 8581 aacggctgcg ggcagggctg ctgccctcac acctgcctga gtgatagtct agcatattac 8641 ccctaacacc tgccacccca gtcttaatca gtggtggaag aacggtctca gaactgtttg 8701 tctcaattgg ccatttaagt ttaatagtga aagactggtt aatgataaca atgcatcgga 8761 aaaccttcag gaggaaagga gaatgttttg tggaacattt ttgtgtgtgt ggcagtttta 8821 agttattagt tttcaaaatc agtacttttt aatggaaaca acttgaccaa aaatctgtca 8881 cagaattttg agacccatta aaatacaagt ttaatgagaa gtctgtctct gttaatgctg 8941 aagtcattac taagtgctta gcttagcaag gtatgtggat gcccatttgt gttccaaggg 9001 attggactgt tcatcaggac ccagagctga gtttcaaggg ctcaagagat ggcttattac 9061 ctgtgggtgt cttgaaggtt ctggttggga caaattagga atgtttttgg cagacatggt 9121 gactaccctt catctgggtg agttcagttg atttgtcttg agcctttggg gtttacacaa 9181 gtaaatgaca tcatacagtt agtgtattgt tagtgaatat taatatatga ggcaggcttt 9241 gctctagcaa ttttagaact agttttcagg aaagggttca tcttgtgcat tggatgtctg 9301 attctatcac ttagagttta aactgaaagt gctcaagagg ttttatttag gctgggatat 9361 aaataagcct ttctgtagct tgtaatggta tcaggaattt aaaaggccat ctggggcaca 9421 aagattaagc agaaaaggta gaaggtgaga ttgggggact ttgagtactt cacacacttt 9481 aatgtgtggg tgctttagtg catatagtac aactgccaga taagggcatc cacatctgat 9541 tgtttggaag gcaccttgtg gtttctggga attcagaatt gggagaaaaa gtgctcccaa 9601 ccgctgaagc ccttggtaat ctgcagggtg tttatttagc aggagataag gacaaaaagt 9661 tatagtgtgg agttggttga gttggtagat gtcattacaa caggtggtct taaattgggt 9721 taggagtcac tttgaaatac ctgggccata agcaaagtgg cattttcacc tttcaggaga 9781 aactggtaca cttatccatt ctatagtgca tgcttgttca attgggctga tgactaaacc 9841 ggtgactaaa ggtttgtcag tataaatgga tgggttgtag gcagacggtg aggaattact 9901 atacctgcaa ggagtcattg cctgatctgc ctggaaaggg gcaggattga gtctcagaag 9961 gtgtacacca taggatatgg aaaaatttgt cacgcctagc attcaactta gtggtgtagc 10021 gccacctact ggcactttaa aagcttagca tagaggagca tgtgtgttag gagctcggat 10081 gggatccagg gcctcaaggt ttgcatgtaa ataaaagccc tttaccaaat taactacata 10141 ccagcataca tcagtccttt agtgttgaaa aacagaagtg aaagctaata tatatagtgc 10201 ttgctttatt taagtctagc tgattacgtg tttggttgcc agtgtgacta gtctggagtt 10261 gaatttgtcc tcagacacgt aaaatggaat ttgggattca caacactcta gtatgaggga 10321 cctaatggcc tgtaccaggc acaaacgtgt ctataaacta cacaaaacga aggaatttac 10381 aggaattagg aaggtattct taacattaaa acattatggg cattttaaaa aaagctttga 10441 caggatttct ttgtcatggc tgtcctggag ctagttgtgt agaccaggct gggctgaaat 10501 cttgtctgcc tgcctggctt ggacactttt ttattatgta tacaacattc tgcttccatg 10561 tatatctgca cattagaaga cggcaccaga tctcctaatg gatggttgtg agccaccatg 10621 tggttgctgg gaattgaact caggacctct ggaagagcag tgctcttaac ctctgagcca 10681 tctccagccc cagcttgggc acatttttaa tggctgggaa atcaaacccc ctaggccttc 10741 tgtcagtaat gaagggcttt tggctaccga gagtaggatt taaggttatt cggagctgca 10801 ggtctgcctc agtgcaggtt tgggagtcca gcatcttaga aaatgcagtg aagccaagct 10861 gagctatatt ttgtttaaaa aaaaaataag tgggtaaagt gctgctgagc ctgatgacca 10921 agctgggaca caagtagaag aacataggcc aatgctctat attaaaagca tgggtcattt 10981 ttaatgctct tgagaaggct atgcctacac tactctcagc caccgcagcg tgtttaaatt 11041 aaactagttt ggaaattttc tttgggggta agctatttaa cctagtgcct tggcaggtat 11101 actactgaac tctcctcctc attccttttt gttttttaag aatttcagtc aggctcaggc 11161 agcccttaaa cttgtgatta agcctgagaa cagttacgat tatgagccta ttagtatacc 11221 gatcaatatg tgaatttttt tgggatgggg gtcaggcctc cctgcctccc aaatactggg 11281 actaaaggct gcaccaccac aacctggctc ttgaaatact tttctacatt ttttgggggg 11341 catgggtggg agagcagggt ttctctgtat tagccctggc tctcctggaa ctctgtagac 11401 caggctattc ttgagctcag attagcctgt ctctgcctcc taaattctgg gattaaaggt 11461 gtgtgctact gctgcctggc tacaaagaca tttttttttt tcttaaattt aaaaacaaaa 11521 gtggttcttt tagaagggtg gttggtgttg gcacatactc caagcactca ggttttgagt 11581 ttgtcccagg aatgaagact gcattactgc cgcccctccc tggtaagggc tacacagaga 11641 aatcctattt ggagcctgtc ctggtaactc gctctgtaga ccaggctggc ctcgaactca 11701 agagaaccac ctgcctctga atgctggtat taagggcagg caccaccaac acccagccta 11761 aaaaatgtct tttttttaaa gatttttttt ttttttttac agaataaaca ttctgtttac 11821 aatattctgc ttctatgtat atctgcacac tagaagaggg cacccgatct cataatggat 11881 ggttgtgagc caccaagtgg ttgctgggaa ttgaactcag aacctctgga agagcagtca 11941 gtgctcttaa cctctgagcc atctctccag cccctaaaaa tggctcttga gatagggtct 12001 caagtagttt gagactgagt tggctatata aacaaggctg gcacatagca ccatgtacag 12061 ctgggtttag tttacatggg gtgtttttgt ctctggaggc aggaggatca tttgagcata 12121 gggagttaat agtgaggtca tgttttatct actcttctga attgagaact aagctgatgc 12181 aaagcaagtt tgactgaaga agtccagttt atgagaacaa gggtggaaac taatgtgtca 12241 aagatggcct tgcatgtgtt ttagatgatg acccagtcac ttgggaatta ctggatgtgt 12301 aagacctata tcttgacagg agtgaacagt gtcttatagg tcctatatga aagaaatgag 12361 acatacccat tttgtttccc ctaagaattc acttttccta acctggttca tgctatttag 12421 gttattttac ttgcaaatcc tagggtgctc ccttacccag tattgcttat gtggcaccaa 12481 agtcactcac tcccatgatt tgcaagtctc tgggaacttc catgacaacc tagaatagca 12541 actcaaatac attttctcag taccaatttt gaagaaaaaa tattttgcaa aatagctgta 12601 tggatgggta ctaaatagtg aggttatctc cagaaggcct atgaagaatt aaggttgagt 12661 tcagttgagt tcagcagcaa gtttaaggtt catccatttt tgtacagtgt tttcctatta 12721 cggtaagtgt tttgcctgca ggaatatctg taccacatgc ttgcctggta cctatatcgg 12781 ccagaagagg gctttggatc ctctggactt gaattacaga tgggtattag ccaccattta 12841 ggtgctggga attgaaacca agtcctctgg aagaacagca agtgactcga cgtccggagc 12901 tctggcgcgc cgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca 12961 ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca 13021 ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc 13081 ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc 13141 catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta 13201 ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga 13261 gcttgtatat ccattttcgg atctgatcag cacgtgatga aaaagcctga actcaccgcg 13321 acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg tctccgacct gatgcagctc 13381 tcggagggcg aagaatctcg tgctttcagc ttcgatgtag gagggcgtgg atatgtcctg 13441 cgggtaaata gctgcgccga tggtttctac aaagatcgtt atgtttatcg gcactttgca 13501 tcggccgcgc tcccgattcc ggaagtgctt gacattgggg aattcagcga gagcctgacc 13561 tattgcatct cccgccgtgc acagggtgtc acgttgcaag acctgcctga aaccgaactg 13621 cccgctgttc tgcagccggt cgcggaggcc atggatgcga tcgctgcggc cgatcttagc 13681 cagacgagcg ggttcggccc attcggaccg caaggaatcg gtcaatacac tacatggcgt 13741 gatttcatat gcgcgattgc tgatccccat gtgtatcact ggcaaactgt gatggacgac 13801 accgtcagtg cgtccgtcgc gcaggctctc gatgagctga tgctttgggc cgaggactgc 13861 cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca acaatgtcct gacggacaat 13921 ggccgcataa cagcggtcat tgactggagc gaggcgatgt tcggggattc ccaatacgag 13981 gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta tggagcagca gacgcgctac 14041 ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc tccgggcgta tatgctccgc 14101 attggtcttg accaactcta tcagagcttg gttgacggca atttcgatga tgcagcttgg 14161 gcgcagggtc gatgcgacgc aatcgtccga tccggagccg ggactgtcgg gcgtacacaa 14221 atcgcccgca gaagcgcggc cgtctggacc gatggctgtg tagaagtact cgccgatagt 14281 ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat agcacgtgct acgagatttc 14341 gattccaccg ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc 14401 tggatgatcc tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt 14461 attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 14521 tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 14581 tgtata //