LOCUS       sequence-10886-e        1935 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-ITPKB
FEATURES             Location/Qualifiers
     source          1..1935
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     CDS             1509..1520
                     /codon_start=1
                     /product="WELQut protease recognition and cleavage site"
                     /label=WELQut site
                     /translation="WELQ"
ORIGIN
        1 atggctgtgt actgctatgc gctcaatagc ctggtgatca tgaatagcgc caacgagatg
       61 aagagcggcg gcggcccggg gcccagtggc agcgagacgc ccccgccccc gaggagggca
      121 gtgctgagcc ccggcagcgt tttcagcccc gggagaggcg cctctttcct cttcccccca
      181 gccgagtcgc tgtcccccga ggagccccgg agccccgggg gctggcggag cggccggcgc
      241 aggctgaata gtagcagcgg cagtggcagc ggcagcagcg gcagtagcgt gagcagccca
      301 agttgggctg gtcgcctgcg aggggaccgg cagcaggtgg tggcagccgg taccctctcc
      361 ccgccagggc cggaggaggc caagaggaag ctgcggatct tgcagcgcga gttgcagaac
      421 gtgcaggtga accagaaagt gggcatgttt gaggcgcaca tccaggcaca gagctccgcc
      481 attcaagcgc cccgcagccc gcgtttgggc agggctcact cgccctcccc gtgccccttc
      541 cgcagcagca gtcagccccc tggaagggtc ctggttcagg gcgcccggag cgaggaacgg
      601 aggacaaagt cctgggggga gcaatgtcca gagacttcag gaaccgactc cgggaggaaa
      661 ggagggccca gcctatgctc ctcgcaggtg aagaaaggaa tgccacctct tcccggccgg
      721 gctgccccta caggatcaga ggctcagggt ccatccgctt ttgtaaggat ggagaagggt
      781 atccctgcca gtccccgctg tggctcaccc acagctatgg aaattgacaa aaggggctct
      841 cctaccccgg gaactcggag ctgcctagct ccctcattgg ggctgttcgg agctagctta
      901 acgatggcca cggaagtggc agcgagagtt acatccactg ggccacaccg tccacaggat
      961 cttgccctca ctgagccgtc tgggagagcc cgtgagcttg aggacctgca gcccccagag
     1021 gccctggtgg agaggcaggg gcagtttctg ggcagtgaga caagcccagc cccagaaagg
     1081 ggcgggcccc gcgatggaga accccctggg aagatgggga aaggatatct gccctgtggc
     1141 atgccgggct ctggggagcc tgaagtgggc aaaaggccag aggagacgac tgtgagcgtg
     1201 caaagcgcag agtcctctga tgccctgagc tggtccaggc tgcccagggc cctggcctcc
     1261 gtaggccctg aggaggcccg aagtggggcc cccgtgggcg gggggcgttg gcagctctcc
     1321 gacagagtgg agggagggtc cccaacgctg ggcttgcttg ggggcagccc ctcagcacag
     1381 ccggggaccg ggaatgtgga ggcgggaatt ccttctggca gaatgctgga gcctttgccc
     1441 tgttgggacg ctgcgaaaga tctgaaagaa cctcagtgcc ctcctgggga cagggtgggt
     1501 gtgcagcctg ggaactccag ggtttggcag ggcaccatgg agaaagccgg tttggcttgg
     1561 acgcgtggca caggggtgca atcagagggg acttgggaaa gccagcggca ggacagtgat
     1621 gccctcccaa gtccggagct gctaccccaa gatcaggaca agcctttcct gaggaaggcc
     1681 tgcagcccca gcaacatacc tgctgtcatc attacagaca tgggcaccca ggaggatggg
     1741 gccttggagg agacgcaggg aagccctcgg ggcaacctgc ccctgaggaa actgtcctct
     1801 tcctcggcct cctccacggg cttctcctca tcctacgaag actcagagga ggacatctcc
     1861 agtgaccctg agcgcaccct ggaccccaac tcagccttcc tgcataccct ggaccagcag
     1921 aaacctagag tgtga
//
