LOCUS       sequence-137121-        2469 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  natural linear DNA
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 2469)
  AUTHORS   Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA,
            Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, 
            Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao 
            JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM,
            Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, 
            Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA
  TITLE     COT drives resistance to RAF inhibition through MAP kinase pathway 
            reactivation.
  JOURNAL   Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627
  PUBMED    21107320
REFERENCE   2  (bases 1 to 2469)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; doi: "10"; journalName: 
            "Nature"; date: "2010-12-16- 16"; volume: "468"; issue: "7326"; 
            pages: "968-72"
COMMENT     Sequence Label: pDONR223-FGFR2
FEATURES             Location/Qualifiers
     source          1..2469
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     protein_bind    397..408
                     /label=ZF binding site
                     /bound_moiety="CCR5TC zinc-finger domain"
                     /note="target sequence for the CCR5TC zinc-finger domain 
                     from the CCR5-224 (+) zinc-finger nuclease (Perez et al., 
                     2008; Gross et al., 2013)"
ORIGIN
        1 atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg
       61 gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc
      121 aaataccaaa tctctcaacc agaagtgtac gtggatgcgc caggggagtc gctagaggtg
      181 cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg
      241 cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga
      301 gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc
      361 atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg
      421 gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa
      481 aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca
      541 gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag
      601 gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt
      661 gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc
      721 aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc
      781 ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt
      841 tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa
      901 tacgggcccg acgggctgcc ctacctcaag gttctcaagc actcggggat aaatagttcc
      961 aatgcagaag tgctggctct gttcaatgtg accgaggcgg atgctgggga atatatatgt
     1021 aaggtctcca attatatagg gcaggccaac cagtctgcct ggctcactgt cctgccaaaa
     1081 cagcaagcgc ctggaagaga aaaggagatt acagcttccc cagactacct ggagatagcc
     1141 atttactgca taggggtctt cttaatcgcc tgtatggtgg taacagtcat cctgtgccga
     1201 atgaagaaca cgaccaagaa gccagacttc agcagccagc cggctgtgca caagctgacc
     1261 aaacgtatcc ccctgcggag acaggtaaca gtttcggctg agtccagctc ctccatgaac
     1321 tccaacaccc cgctggtgag gataacaaca cgcctctctt caacggcaga cacccccatg
     1381 ctggcagggg tctccgagta tgaacttcca gaggacccaa aatgggagtt tccaagagat
     1441 aagctgacac tgggcaagcc cctgggagaa ggttgctttg ggcaagtggt catggcggaa
     1501 gcagtgggaa ttgacaaaga caagcccaag gaggcggtca ccgtggccgt gaagatgttg
     1561 aaagatgatg ccgcagagaa agacctttct gatctggtgt cagagatgga gatgatgaag
     1621 atgattggga aacacaagaa tatcataaat cttcttggag cctgcacaca ggatgggcct
     1681 ctctatgtca tagttgagta tgcctctaaa ggcaacctcc gagaatacct ccgagcccgg
     1741 aggccacccg ggatggagta ctcctatgac attaaccgtg ttcctgagga gcagatgacc
     1801 ttcaaggact tggtgtcatg cacctaccag ctggccagag gcatggagta cttggcttcc
     1861 caaaaatgta ttcatcgaga tttagcagcc agaaatgttt tggtaacaga aaacaatgtg
     1921 atgaaaatag cagactttgg actcgccaga gatatcaaca atatagacta ttacaaaaag
     1981 accaccaatg ggcggcttcc agtcaagtgg atggctccag aagccctgtt tgatagagta
     2041 tacactcatc agagtgatgt ctggtccttc ggggtgttaa tgtgggagat cttcacttta
     2101 gggggctcgc cctacccagg gattcccgtg gaggaacttt ttaagctgct gaaggaagga
     2161 cacagaatgg ataagccagc caactgcacc aacgaactgt acatgatgat gagggactgt
     2221 tggcatgcag tgccctccca gagaccaacg ttcaagcagt tggtagaaga cttggatcga
     2281 attctcactc tcacaaccaa tgaggaatac ttggacctca gccaacctct cgaacagtat
     2341 tcacctagtt accctgacac aagaagttct tgttcttcag gagatgattc tgttttttct
     2401 ccagacccca tgccttacga accatgcctt cctcagtatc cacacataaa cggcagtgtt
     2461 aaaacatga
//
