LOCUS       sequence-223311-        1034 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  CRISPR-mediated activation of human islet enhancer containing 
            T2D-associated variant rs7903146 (TCF7L2 GWAS locus).
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 1034)
  AUTHORS   Miguel-Escalada I, Bonas-Guarch S, Cebola I, Ponsa-Cobas J, 
            Mendieta-Esteban J, Atla G, Javierre BM, Rolando DMY, Farabella I, 
            Morgan CC, Garcia-Hurtado J, Beucher A, Moran I, Pasquali L, 
            Ramos-Rodriguez M, Appel EVR, Linneberg A, Gjesing AP, Witte DR, 
            Pedersen O, Grarup N, Ravassard P, Torrents D, Mercader JM, Piemonti
            L, Berney T, de Koning EJP, Kerr-Conte J, Pattou F, Fedko IO, Groop 
            L, Prokopenko I, Hansen T, Marti-Renom MA, Fraser P, Ferrer J
  TITLE     Human pancreatic islet three-dimensional chromatin architecture 
            provides insights into the genetics of type 2 diabetes.
  JOURNAL   Nat Genet. 2019 Jun 28. pii: 10.1038/s41588-019-0457-0. doi: 
            10.1038/s41588-019-0457-0.
  PUBMED    31253982
REFERENCE   2  (bases 1 to 1034)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat Genet. 
            2019 Jun 28. pii: 10.1038/s41588-019-0457-0. doi: 
            10.1038/s41588-019-0457-0."
COMMENT     Sequence Label: lentiSAMv2 rs7903146-guide3
FEATURES             Location/Qualifiers
     source          1..1034
                     /mol_type="genomic DNA"
                     /organism="unspecified"
     gap             11..22
                     /estimated_length=12
     misc_RNA        68..86
                     /label=MS2 stem loop
                     /note="stem loop that binds the bacteriophage MS2 coat 
                     protein"
     misc_RNA        138..156
                     /label=MS2 stem loop
                     /note="stem loop that binds the bacteriophage MS2 coat 
                     protein"
     gap             337..351
                     /estimated_length=15
     gap             398..408
                     /estimated_length=11
     gap             540..549
                     /estimated_length=10
     gap             770..780
                     /estimated_length=11
     gap             819..835
                     /estimated_length=17
     gap             889..899
                     /estimated_length=11
     gap             998..1014
                     /estimated_length=17
ORIGIN
        1 tnnnnnnnng nnnnnnnnnn nngaancacc gacgagaaac cacagttaca gttttagagc
       61 taggccaaca tgaggatcac ccatgtctgc agggcctagc aagttaaaat aaggctagtc
      121 cgttatcaac ttggccaaca tgaggatcac ccatgtctgc agggccaagt ggcaccgagt
      181 cggtgctttt tttggatcct aggtcttgaa aggagtggga attggctccg gtgcccgtca
      241 gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg tcggnanttg
      301 atccggtgcc tagagaaggt ggcgcgnngt aanntgnnnn nnnnnnnnnn ngnnnngnct
      361 ccgnnnttnn cnnnatggtn nnnnangacn nnnnnnannn nnnnnnnngt tgngnnngnn
      421 nnnnnannnn nangnnnatn ncnnnnncng caagntnagn ntgannttcn tctgnnnanc
      481 nnnnanntnn ccgtgnnntg nnnntnnntn nnnnnnncct tnnnnnncng nnnnnnnngn
      541 nnnnnnnnnt annncnacca catgaancan nncgacntcn ncnntcnnnn ntgcccnann
      601 nnnncntnnn nnannggcan nnnnntnnnn nnngannann nnnnntnnnn gagccnnnnn
      661 nnanntgnnn nncnnnnnnn acnnncnnnn nnannnnnnt cnnnntnann gnnatcnnan
      721 nnnnnngnnn anngnnncnn nnnnggggca nnnnnntnng nnnannnnan nnnnnnnnnn
      781 angtcnannn nannnncnan nnntnntnnn nacggnntnn nnnnnnnnnn nnnnnanncn
      841 nnanaanatn nnnannnnnn nnntgcnnnn tcnncnannn ttnnnngtnn nnnnnnnnnt
      901 nnnnnnantn nnnnnnnnta ntgnnnnnnn ncnnntanct nnangtannn nnnnncnnnn
      961 nnaannnnnn cnnnnnnnan nnannntctc ntnnnctnnn nnnnnnnnnn nnnngnnnan
     1021 nnngannnnn nnta
//
