LOCUS       sequence-453300-       19163 bp    DNA     circular SYN 15-DEC-2025
DEFINITION  T-DNA vector for PmCDA1-CBE_V04 based C-to-T base editing for dicot 
            plants; NGG PAM; 5' editing window; PmCDA1-CBE_V04 was driven by 
            AtUBQ10 and sgRNA was driven by AtU3; Hygromycin for plants select..
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      synthetic DNA construct
  ORGANISM  synthetic DNA construct
REFERENCE   1  (bases 1 to 19163)
  AUTHORS   Cheng Y, Li G, Qi A, Mandlik R, Pan C, Wang D, Ge S, Qi Y
  TITLE     A comprehensive all-in-one CRISPR toolbox for large-scale screens in
            plants.
  JOURNAL   Plant Cell. 2025 Apr 9:koaf081. doi: 10.1093/plcell/koaf081.
  PUBMED    40202185
REFERENCE   2  (bases 1 to 19163)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Plant Cell.
            2025 Apr 9:koaf081. doi: 10.1093/plcell/koaf081."
COMMENT     Sequence Label: pYPQAT25
FEATURES             Location/Qualifiers
     source          1..19163
                     /mol_type="other DNA"
                     /organism="synthetic DNA construct"
     primer_bind     164..184
                     /label=35S promoter
                     /note="CaMV 35S promoter, forward primer"
     promoter        173..219
                     /label=minimal CaMV 35S promoter
                     /note="minimal 35S promoter from cauliflower mosaic virus"
     CDS             294..1319
                     /codon_start=1
                     /product="hygromycin B phosphotransferase"
                     /label=HygR
                     /note="confers resistance to hygromycin"
                     /translation="MKKPELTATSVEKFLIEKFDSVSDLMQLSEGEESRAFSFDVGGRG
                     YVLRVNSCADGFYKDRYVYRHFASAALPIPEVLDIGEFSESLTYCISRRSQGVTLQDLP
                     ETELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIADPHVYHWQ
                     TVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLTDNGRITAVIDWSEAMF
                     GDSQYEVANIFFWRPWLACMEQQTRYFERRHPELAGSPRLRAYMLRIGLDQLYQSLVDG
                     NFDDAAWAQGRCDAIVRSGAGTVGRTQIARRSAAVWTDGCVEVLADSGNRRPSTRPRAK
                     K"
     polyA_signal    1360..1534
                     /label=CaMV poly(A) signal
                     /note="cauliflower mosaic virus polyadenylation signal"
     misc_feature    1612..1636
                     /label=LB T-DNA repeat
                     /note="left border repeat from nopaline C58 T-DNA"
     CDS             3260..4054
                     /codon_start=1
                     /gene="aphA-3"
                     /product="aminoglycoside phosphotransferase"
                     /label=KanR
                     /note="confers resistance to kanamycin"
                     /translation="MAKMRISPELKKLIEKYRCVKDTEGMSPAKVYKLVGENENLYLKM
                     TDSRYKGTTYDVEREKDMMLWLEGKLPVPKVLHFERHDGWSNLLMSEADGVLCSEEYED
                     EQSPEKIIELYAECIRLFHSIDISDCPYTNSLDSRLAELDYLLNNDLADVDCENWEEDT
                     PFKDPRELYDFLKTEKPEEELVFSHGDLGDSNIFVKDGKVSGFIDLGRSGRADKWYDIA
                     FCVRSIREDIGEEQYVELFFDLLGIKPDWEKIKYYILLDELF"
     rep_origin      4141..4729
                     /direction=RIGHT
                     /label=ori
                     /note="high-copy-number ColE1/pMB1/pBR322/pUC origin of 
                     replication"
     primer_bind     4630..4649
                     /label=pBR322ori-F
                     /note="pBR322 origin, forward primer"
     primer_bind     4883..4900
                     /label=L4440
                     /note="L4440 vector, forward primer"
     misc_feature    4915..5055
                     /label=bom
                     /note="basis of mobility region from pBR322"
     primer_bind     complement(4981..5000)
                     /label=pRS-marker
                     /note="pRS vectors, use to sequence yeast selectable 
                     marker"
     primer_bind     5141..5163
                     /label=pGEX 3'
                     /note="pGEX vectors, reverse primer"
     rep_origin      5399..5593
                     /label=pVS1 oriV
                     /note="origin of replication for the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
     CDS             complement(5659..6732)
                     /codon_start=1
                     /product="replication protein from the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
                     /label=pVS1 RepA
                     /translation="MSGRKPSGPVQIGAALGDDLVEKLKAAQAAQRQRIEAEARPGESW
                     QAAADRIRKESRQPPAAGAPSIRKPPKGDEQPDFFVPMLYDVGTRDSRSIMDVAVFRLS
                     KRDRRAGEVIRYELPDGHVEVSAGPAGMASVWDYDLVLMAVSHLTESMNRYREGKGDKP
                     GRVFRPHVADVLKFCRRADGGKQKDDLVETCIRLNTTHVAMQRTKKAKNGRLVTVSEGE
                     ALISRYKIVKSETGRPEYIEIELADWMYREITEGKNPDVLTVHPDYFLIDPGIGRFLYR
                     LARRAAGKAEARWLFKTIYERSGSAGEFKKFCFTVRKLIGSNDLPEYDLKEEAGQAGPI
                     LVMRYRNLIEGEASAGS"
     CDS             complement(7161..7790)
                     /codon_start=1
                     /product="stability protein from the Pseudomonas plasmid 
                     pVS1 (Heeb et al., 2000)"
                     /label=pVS1 StaA
                     /translation="MKVIAVLNQKGGSGKTTIATHLARALQLAGADVLLVDSDPQGSAR
                     DWAAVREDQPLTVVGIDRPTIDRDVKAIGRRDFVVIDGAPQAADLAVSAIKAADFVLIP
                     VQPSPYDIWATADLVELVKQRIEVTDGRLQAAFVVSRAIKGTRIGGEVAEALAGYELPI
                     LESRITQRVSYPGTAAAGTTVLESEPEGDAAREVQALAAEIKSKLI"
     misc_feature    9091..9115
                     /label=RB T-DNA repeat
                     /note="right border repeat from nopaline C58 T-DNA"
     primer_bind     9318..9334
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    10017..10041
                     /gene="mutant version of attB"
                     /label=attB1
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
     CDS             10063..10128
                     /codon_start=1
                     /product="three tandem FLAG(R) epitope tags, followed by an
                     enterokinase cleavage site"
                     /label=3xFLAG
                     /translation="DYKDHDGDYKDHDIDYKDDDDK"
     CDS             10135..10155
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             join(10180..10203,10204..10206,10207..14280)
                     /codon_start=1
                     /product="nickase mutant of the Cas9 endonuclease from the 
                     Streptococcus pyogenes Type II CRISPR/Cas system"
                     /label=Cas9(D10A)
                     /note="generates RNA-guided single strand nicks in DNA due 
                     to the D10A mutation in the RuvC catalytic domain"
                     /translation="DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKN
                     LIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESF
                     LVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKF
                     RGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLE
                     NLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQI
                     GDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQ
                     QLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLR
                     KQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGN
                     SRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYF
                     TVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDS
                     VEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL
                     KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQ
                     LIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRH
                     KPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYL
                     YYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPS
                     EEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHV
                     AQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLN
                     AVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTE
                     ITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKE
                     SILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGIT
                     IMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNEL
                     ALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADA
                     NLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLD
                     ATLIHQSITGLYETRIDLSQLGGD"
     RBS             14193..14201
                     /label=Shine-Dalgarno sequence
                     /note="full consensus sequence for ribosome-binding sites 
                     upstream of start codons in E. coli; complementary to a 
                     region in the 3' end of the 16S rRNA (Chen et al., 1994)"
     CDS             14281..14328
                     /codon_start=1
                     /product="bipartite nuclear localization signal from 
                     nucleoplasmin"
                     /label=nucleoplasmin NLS
                     /translation="KRPAATKKAGQAKKKK"
     CDS             14545..14610
                     /codon_start=1
                     /product="three tandem FLAG(R) epitope tags, followed by an
                     enterokinase cleavage site"
                     /label=3xFLAG
                     /translation="DYKDHDGDYKDHDIDYKDDDDK"
     CDS             15244..15264
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             15271..15522
                     /codon_start=1
                     /product="uracil-DNA glycosylase inhibitor from a Bacillus 
                     subtilis bacteriophage (Mol et al., 1995)"
                     /label=UGI
                     /translation="MTNLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDILVHT
                     AYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIKML"
     CDS             15523..15576
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     CDS             15751..15804
                     /codon_start=1
                     /product="2A peptide from Thosea asigna virus capsid 
                     protein"
                     /label=T2A
                     /note="Eukaryotic ribosomes fail to insert a peptide bond 
                     between the Gly and Pro residues, yielding separate 
                     polypeptides."
                     /translation="EGRGSLLTCGDVEENPGP"
     CDS             15811..15831
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             15859..16245
                     /codon_start=1
                     /product="bacteriophage MS2 coat protein"
                     /label=MS2-N55K
                     /note="binds with high affinity to a specific stem-loop 
                     structure in the viral RNA (Lim et al., 1994)"
                     /translation="ASNFTQFVLVDNGGTGDVTVAPSNFANGVAEWISSNSRSQAYKVT
                     CSVRQSSAQKRKYTIKVEVPKVATQTVGGVELPVAAWRSYLNMELTIPIFATNSDCELI
                     VKAMQGLLKDGNPIPSAIAANSGIY"
     CDS             16294..16542
                     /codon_start=1
                     /product="uracil-DNA glycosylase inhibitor from a Bacillus 
                     subtilis bacteriophage (Mol et al., 1995)"
                     /label=UGI
                     /translation="TNLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDILVHTA
                     YDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIKML"
     CDS             16555..16575
                     /codon_start=1
                     /product="nuclear localization signal of SV40 (simian virus
                     40) large T antigen"
                     /label=SV40 NLS
                     /translation="PKKKRKV"
     CDS             16582..16629
                     /codon_start=1
                     /product="bipartite nuclear localization signal from 
                     nucleoplasmin"
                     /label=nucleoplasmin NLS
                     /translation="KRPAATKKAGQAKKKK"
     terminator      16651..16903
                     /label=NOS terminator
                     /note="nopaline synthase terminator and poly(A) signal"
     protein_bind    16948..16968
                     /gene="mutant version of attB"
                     /label=attB5
                     /bound_moiety="BP Clonase(TM)"
                     /note="core recombination site for the Gateway(R) BP 
                     reaction"
     CDS             complement(17329..17634)
                     /codon_start=1
                     /gene="lacZ fragment"
                     /product="LacZ-alpha fragment of beta-galactosidase"
                     /label=lacZ-alpha
                     /translation="MTMITPSAQLTLTKGNKSWRTSRGGPVPNSPYSESYYARSLAVVL
                     QRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWDAPCSGAGL"
     primer_bind     17499..17515
                     /label=M13 fwd
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     primer_bind     17525..17544
                     /label=T7
                     /note="T7 promoter, forward primer"
     promoter        17525..17543
                     /label=T7 promoter
                     /note="promoter for bacteriophage T7 RNA polymerase"
     primer_bind     complement(17591..17611)
                     /label=T3
                     /note="T3 promoter, forward primer"
     promoter        complement(17591..17609)
                     /label=T3 promoter
                     /note="promoter for bacteriophage T3 RNA polymerase"
     primer_bind     complement(17630..17646)
                     /label=M13 rev
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    17654..17670
                     /label=lac operator
                     /bound_moiety="lac repressor encoded by lacI"
                     /note="The lac repressor binds to the lac operator to 
                     inhibit transcription in E. coli. This inhibition can be 
                     relieved by adding lactose or 
                     isopropyl-beta-D-thiogalactopyranoside (IPTG)."
     promoter        complement(join(17678..17684,17685..17702,17703..17708))
                     /label=lac promoter
                     /note="promoter for the E. coli lac operon"
     protein_bind    17723..17744
                     /label=CAP binding site
                     /bound_moiety="E. coli catabolite activator protein"
                     /note="CAP binding activates transcription in the presence 
                     of cAMP."
     misc_RNA        17803..17821
                     /label=MS2 stem loop
                     /note="stem loop that binds the bacteriophage MS2 coat 
                     protein"
     misc_RNA        17873..17891
                     /label=MS2 stem loop
                     /note="stem loop that binds the bacteriophage MS2 coat 
                     protein"
     protein_bind    complement(18124..18148)
                     /gene="mutant version of attB"
                     /label=attB2
                     /bound_moiety="BP Clonase(TM)"
                     /note="recombination site for the Gateway(R) BP reaction"
     terminator      18212..18464
                     /label=NOS terminator
                     /note="nopaline synthase terminator and poly(A) signal"
     primer_bind     complement(18481..18497)
                     /label=M13 rev
                     /note="common sequencing primer, one of multiple similar 
                     variants"
     protein_bind    18505..18521
                     /label=lac operator
                     /bound_moiety="lac repressor encoded by lacI"
                     /note="The lac repressor binds to the lac operator to 
                     inhibit transcription in E. coli. This inhibition can be 
                     relieved by adding lactose or 
                     isopropyl-beta-D-thiogalactopyranoside (IPTG)."
     promoter        complement(join(18529..18535,18536..18553,18554..18559))
                     /label=lac promoter
                     /note="promoter for the E. coli lac operon"
     protein_bind    18574..18595
                     /label=CAP binding site
                     /bound_moiety="E. coli catabolite activator protein"
                     /note="CAP binding activates transcription in the presence 
                     of cAMP."
ORIGIN
        1 aaggaaaggc tatcgttcaa gatgcctctg ccgacagtgg tcccaaagat ggacccccac
       61 ccacgaggag catcgtggaa aaagaagacg ttccaaccac gtcttcaaag caagtggatt
      121 gatgtgatat ctccactgac gtaagggatg acgcacaatc ccactatcct tcgcaagacc
      181 cttcctctat ataaggaagt tcatttcatt tggagaggac acgctgaaat caccagtctc
      241 tctctacaaa tctatctctc tcgagctttc gcagatccgg ggggcaatga gatatgaaaa
      301 agcctgaact caccgcgacg tctgtcgaga agtttctgat cgaaaagttc gacagcgtct
      361 ccgacctgat gcagctctcg gagggcgaag aatctcgtgc tttcagcttc gatgtaggag
      421 ggcgtggata tgtcctgcgg gtaaatagct gcgccgatgg tttctacaaa gatcgttatg
      481 tttatcggca ctttgcatcg gccgcgctcc cgattccgga agtgcttgac attggggagt
      541 ttagcgagag cctgacctat tgcatctccc gccgttcaca gggtgtcacg ttgcaagacc
      601 tgcctgaaac cgaactgccc gctgttctac aaccggtcgc ggaggctatg gatgcgatcg
      661 ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa ggaatcggtc
      721 aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg tatcactggc
      781 aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat gagctgatgc
      841 tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc ggctccaaca
      901 atgtcctgac ggacaatggc cgcataacag cggtcattga ctggagcgag gcgatgttcg
      961 gggattccca atacgaggtc gccaacatct tcttctggag gccgtggttg gcttgtatgg
     1021 agcagcagac gcgctacttc gagcggaggc atccggagct tgcaggatcg ccacgactcc
     1081 gggcgtatat gctccgcatt ggtcttgacc aactctatca gagcttggtt gacggcaatt
     1141 tcgatgatgc agcttgggcg cagggtcgat gcgacgcaat cgtccgatcc ggagccggga
     1201 ctgtcgggcg tacacaaatc gcccgcagaa gcgcggccgt ctggaccgat ggctgtgtag
     1261 aagtactcgc cgatagtgga aaccgacgcc ccagcactcg tccgagggca aagaaataga
     1321 gtagatgccg accgggatct gtcgatcgac aagctcgagt ttctccataa taatgtgtga
     1381 gtagttccca gataagggaa ttagggttcc tatagggttt cgctcatgtg ttgagcatat
     1441 aagaaaccct tagtatgtat ttgtatttgt aaaatacttc tatcaataaa atttctaatt
     1501 cctaaaacca aaatccagta ctaaaatcca gatcccccga attaattcgg cgttaattca
     1561 gtacattaaa aacgtccgca atgtgttatt aagttgtcta agcgtcaatt tgtttacacc
     1621 acaatatatc ctgccaccag ccagccaaca gctccccgac cggcagctcg gcacaaaatc
     1681 accactcgat acaggcagcc catcagtccg ggacggcgtc agcgggagag ccgttgtaag
     1741 gcggcagact ttgctcatgt taccgatgct attcggaaga acggcaacta agctgccggg
     1801 tttgaaacac ggatgatctc gcggagggta gcatgttgat tgtaacgatg acagagcgtt
     1861 gctgcctgtg atcaccgcgg tttcaaaatc ggctccgtcg atactatgtt atacgccaac
     1921 tttgaaaaca actttgaaaa agctgttttc tggtatttaa ggttttagaa tgcaaggaac
     1981 agtgaattgg agttcgtctt gttataatta gggaaggtgc gaacaagtcc ctgatatgag
     2041 atcatgtttg tcatctggag ccatagaaca gggttcatca tgagtcatca acttaccttc
     2101 gccgacagtg aattcagcag taagcgccgt cagaccagaa aagagatttt cttgtcccgc
     2161 atggagcaga ttctgccatg gcaaaacatg gtggaagtca tcgagccgtt ttaccccaag
     2221 gctggtaatg gccggcgacc ttatccgctg gaaaccatgc tacgcattca ctgcatgcag
     2281 cattggtaca acctgagcga tggcgcgatg gaagatgctc tgtacgaaat cgcctccatg
     2341 cgtctgtttg cccggttatc cctggatagc gccttgccgg accgcaccac catcatgaat
     2401 ttccgccacc tgctggagca gcatcaactg gcccgccaat tgttcaagac catcaatcgc
     2461 tggctggccg aagcaggcgt catgatgact caaggcacct tggtcgatgc caccatcatt
     2521 gaggcaccca gctcgaccaa gaacaaagag cagcaacgcg atccggagat gcatcagacc
     2581 aagaaaggca atcagtggca ctttggcatg aaggcccaca ttggtgtcga tgccaagagt
     2641 ggcctgaccc acagcctggt caccaccgcg gccaacgagc atgacctcaa tcagctgggt
     2701 aatctgctgc atggagagga gcaatttgtc tcagccgatg ccggctacca aggggcgcca
     2761 cagcgcgagg agctggccga ggtggatgtg gactggctga tcgccgagcg ccccggcaag
     2821 gtaagaacct tgaaacagca tccacgcaag aacaaaacgg ccatcaacat cgaatacatg
     2881 aaagccagca tccgggccag ggtggagcac ccatttcgca tcatcaagcg acagttcggc
     2941 ttcgtgaaag ccagatacaa ggggttgctg aaaaacgata accaactggc gatgttattc
     3001 acgctggcca acctgtttcg ggcggaccaa atgatacgtc agtgggagag atctcactaa
     3061 aaactgggga taacgcctta aatggcgaag aaacggtcta aataggctga ttcaaggcat
     3121 ttacgggaga aaaaatcggc tcaaacatga agaaatgaaa tgactgagtc agccgagaag
     3181 aatttccccg cttattcgca ccttccttag cttcttgggg tatctttaaa tactgtagaa
     3241 aagaggaagg aaataataaa tggctaaaat gagaatatca ccggaattga aaaaactgat
     3301 cgaaaaatac cgctgcgtaa aagatacgga aggaatgtct cctgctaagg tatataagct
     3361 ggtgggagaa aatgaaaacc tatatttaaa aatgacggac agccggtata aagggaccac
     3421 ctatgatgtg gaacgggaaa aggacatgat gctatggctg gaaggaaagc tgcctgttcc
     3481 aaaggtcctg cactttgaac ggcatgatgg ctggagcaat ctgctcatga gtgaggccga
     3541 tggcgtcctt tgctcggaag agtatgaaga tgaacaaagc cctgaaaaga ttatcgagct
     3601 gtatgcggag tgcatcaggc tctttcactc catcgacata tcggattgtc cctatacgaa
     3661 tagcttagac agccgcttag ccgaattgga ttacttactg aataacgatc tggccgatgt
     3721 ggattgcgaa aactgggaag aagacactcc atttaaagat ccgcgcgagc tgtatgattt
     3781 tttaaagacg gaaaagcccg aagaggaact tgtcttttcc cacggcgacc tgggagacag
     3841 caacatcttt gtgaaagatg gcaaagtaag tggctttatt gatcttggga gaagcggcag
     3901 ggcggacaag tggtatgaca ttgccttctg cgtccggtcg atcagggagg atatcgggga
     3961 agaacagtat gtcgagctat tttttgactt actggggatc aagcctgatt gggagaaaat
     4021 aaaatattat attttactgg atgaattgtt ttagtaccta gaatgcatga ccaaaatccc
     4081 ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc
     4141 ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc
     4201 agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt
     4261 cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt
     4321 caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc
     4381 tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa
     4441 ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac
     4501 ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg
     4561 gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga
     4621 gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact
     4681 tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa
     4741 cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc
     4801 gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg
     4861 ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcctgat
     4921 gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt gcactctcag
     4981 tacaatctgc tctgatgccg catagttaag ccagtataca ctccgctatc gctacgtgac
     5041 tgggtcatgg ctgcgccccg acacccgcca acacccgctg acgcgccctg acgggcttgt
     5101 ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag
     5161 aggttttcac cgtcatcacc gaaacgcgcg aggcagggtg ccttgatgtg ggcgccggcg
     5221 gtcgagtggc gacggcgcgg cttgtccgcg ccctggtaga ttgcctggcc gtaggccagc
     5281 catttttgag cggccagcgg ccgcgatagg ccgacgcgaa gcggcggggc gtagggagcg
     5341 cagcgaccga agggtaggcg ctttttgcag ctcttcggct gtgcgctggc cagacagtta
     5401 tgcacaggcc aggcgggttt taagagtttt aataagtttt aaagagtttt aggcggaaaa
     5461 atcgcctttt ttctctttta tatcagtcac ttacatgtgt gaccggttcc caatgtacgg
     5521 ctttgggttc ccaatgtacg ggttccggtt cccaatgtac ggctttgggt tcccaatgta
     5581 cgtgctatcc acaggaaaca gaccttttcg acctttttcc cctgctaggg caatttgccc
     5641 tagcatctgc tccgtacatt aggaaccggc ggatgcttcg ccctcgatca ggttgcggta
     5701 gcgcatgact aggatcgggc cagcctgccc cgcctcctcc ttcaaatcgt actccggcag
     5761 gtcatttgac ccgatcagct tgcgcacggt gaaacagaac ttcttgaact ctccggcgct
     5821 gccactgcgt tcgtagatcg tcttgaacaa ccatctggct tctgccttgc ctgcggcgcg
     5881 gcgtgccagg cggtagagaa aacggccgat gccgggatcg atcaaaaagt aatcggggtg
     5941 aaccgtcagc acgtccgggt tcttgccttc tgtgatctcg cggtacatcc aatcagctag
     6001 ctcgatctcg atgtactccg gccgcccggt ttcgctcttt acgatcttgt agcggctaat
     6061 caaggcttca ccctcggata ccgtcaccag gcggccgttc ttggccttct tcgtacgctg
     6121 catggcaacg tgcgtggtgt ttaaccgaat gcaggtttct accaggtcgt ctttctgctt
     6181 tccgccatcg gctcgccggc agaacttgag tacgtccgca acgtgtggac ggaacacgcg
     6241 gccgggcttg tctcccttcc cttcccggta tcggttcatg gattcggtta gatgggaaac
     6301 cgccatcagt accaggtcgt aatcccacac actggccatg ccggccggcc ctgcggaaac
     6361 ctctacgtgc ccgtctggaa gctcgtagcg gatcacctcg ccagctcgtc ggtcacgctt
     6421 cgacagacgg aaaacggcca cgtccatgat gctgcgacta tcgcgggtgc ccacgtcata
     6481 gagcatcgga acgaaaaaat ctggttgctc gtcgcccttg ggcggcttcc taatcgacgg
     6541 cgcaccggct gccggcggtt gccgggattc tttgcggatt cgatcagcgg ccgcttgcca
     6601 cgattcaccg gggcgtgctt ctgcctcgat gcgttgccgc tgggcggcct gcgcggcctt
     6661 caacttctcc accaggtcat cacccagcgc cgcgccgatt tgtaccgggc cggatggttt
     6721 gcgaccgctc acgccgattc ctcgggcttg ggggttccag tgccattgca gggccggcag
     6781 gcaacccagc cgcttacgcc tggccaaccg cccgttcctc cacacatggg gcattccacg
     6841 gcgtcggtgc ctggttgttc ttgattttcc atgccgcctc ctttagccgc taaaattcat
     6901 ctactcattt attcatttgc tcatttactc tggtagctgc gcgatgtatt cagatagcag
     6961 ctcggtaatg gtcttgcctt ggcgtaccgc gtacatcttc agcttggtgt gatcctccgc
     7021 cggcaactga aagttgaccc gcttcatggc tggcgtgtct gccaggctgg ccaacgttgc
     7081 agccttgctg ctgcgtgcgc tcggacggcc ggcacttagc gtgtttgtgc ttttgctcat
     7141 tttctcttta cctcattaac tcaaatgagt tttgatttaa tttcagcggc cagcgcctgg
     7201 acctcgcggg cagcgtcgcc ctcgggttct gattcaagaa cggttgtgcc ggcggcggca
     7261 gtgcctgggt agctcacgcg ctgcgtgata cgggactcaa gaatgggcag ctcgtacccg
     7321 gccagcgcct cggcaacctc accgccgatg cgcgtgcctt tgatcgcccg cgacacgaca
     7381 aaggccgctt gtagccttcc atccgtgacc tcaatgcgct gcttaaccag ctccaccagg
     7441 tcggcggtgg cccatatgtc gtaagggctt ggctgcaccg gaatcagcac gaagtcggct
     7501 gccttgatcg cggacacagc caagtccgcc gcctggggcg ctccgtcgat cactacgaag
     7561 tcgcgccggc cgatggcctt cacgtcgcgg tcaatcgtcg ggcggtcgat gccgacaacg
     7621 gttagcggtt gatcttcccg cacggccgcc caatcgcggg cactgccctg gggatcggaa
     7681 tcgactaaca gaacatcggc cccggcgagt tgcagggcgc gggctagatg ggttgcgatg
     7741 gtcgtcttgc ctgacccgcc tttctggtta agtacagcga taaccttcat gcgttcccct
     7801 tgcgtatttg tttatttact catcgcatca tatacgcagc gaccgcatga cgcaagctgt
     7861 tttactcaaa tacacatcac ctttttagac ggcggcgctc ggtttcttca gcggccaagc
     7921 tggccggcca ggccgccagc ttggcatcag acaaaccggc caggatttca tgcagccgca
     7981 cggttgagac gtgcgcgggc ggctcgaaca cgtacccggc cgcgatcatc tccgcctcga
     8041 tctcttcggt aatgaaaaac ggttcgtcct ggccgtcctg gtgcggtttc atgcttgttc
     8101 ctcttggcgt tcattctcgg cggccgccag ggcgtcggcc tcggtcaatg cgtcctcacg
     8161 gaaggcaccg cgccgcctgg cctcggtggg cgtcacttcc tcgctgcgct caagtgcgcg
     8221 gtacagggtc gagcgatgca cgccaagcag tgcagccgcc tctttcacgg tgcggccttc
     8281 ctggtcgatc agctcgcggg cgtgcgcgat ctgtgccggg gtgagggtag ggcgggggcc
     8341 aaacttcacg cctcgggcct tggcggcctc gcgcccgctc cgggtgcggt cgatgattag
     8401 ggaacgctcg aactcggcaa tgccggcgaa cacggtcaac accatgcggc cggccggcgt
     8461 ggtggtgtcg gcccacggct ctgccaggct acgcaggccc gcgccggcct cctggatgcg
     8521 ctcggcaatg tccagtaggt cgcgggtgct gcgggccagg cggtctagcc tggtcactgt
     8581 cacaacgtcg ccagggcgta ggtggtcaag catcctggcc agctccgggc ggtcgcgcct
     8641 ggtgccggtg atcttctcgg aaaacagctt ggtgcagccg gccgcgtgca gttcggcccg
     8701 ttggttggtc aagtcctggt cgtcggtgct gacgcgggca tagcccagca ggccagcggc
     8761 ggcgctcttg ttcatggcgt aatgtctccg gttctagtcg caagtattct actttatgcg
     8821 actaaaacac gcgacaagaa aacgccagga aaagggcagg gcggcagcct gtcgcgtaac
     8881 ttaggacttg tgcgacatgt cgttttcaga agacggctgc actgaacgtc agaagccgac
     8941 tgcactatag cagcggaggg gttggatcaa agtactttga tcccgagggg aaccctgtgg
     9001 ttggcatgca catacaaatg gacgaacgga taaacctttt cacgcccttt taaatatccg
     9061 attattctaa taaacgctct tttctcttag gtttacccgc caatatatcc tgtcaaacac
     9121 tgatagttta aactgaaggc gggaaacgac aatctgatcc aagctcaagc tgctctagca
     9181 ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt
     9241 acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt
     9301 ttcccagtca cgacgttgta aaacgacggc cagtgccaag ctttcgacga gtcagtaata
     9361 aacggcgtca aagtggttgc agccggcaca cacgagtcgt gtttatcaac tcaaagcaca
     9421 aatacttttc ctcaacctaa aaataaggca attagccaaa aacaactttg cgtgtaaaca
     9481 acgctcaata cacgtgtcat tttattatta gctattgctt caccgcctta gctttctcgt
     9541 gacctagtcg tcctcgtctt ttcttcttct tcttctataa aacaataccc aaagagctct
     9601 tcttcttcac aattcagatt tcaatttctc aaaatcttaa aaactttctc tcaattctct
     9661 ctaccgtgat caaggtaaat ttctgtgttc cttattctct caaaatcttc gattttgttt
     9721 tcgttcgatc ccaatttcgt atatgttctt tggtttagat tctgttaatc ttagatcgaa
     9781 gacgattttc tgggtttgat cgttagatat catcttaatt ctcgattagg gtttcataga
     9841 tatcatccga tttgttcaaa taatttgagt tttgtcgaat aattactctt cgatttgtga
     9901 tttctatcta gatctggtgt tagtttctag tttgtgcgat cgaatttgta gattaatctg
     9961 agtttttctg attaacaggg taccgggccc cccctcgagg cgcgccaagc tatcaaacaa
    10021 gtttgtacaa aaaagcaggc tccgaattcg cccttcacca tggattacaa ggaccacgac
    10081 ggggattaca aggaccacga cattgattac aaggatgatg atgacaagat ggctccgaag
    10141 aagaagagga aggttggcat ccacggggtg ccagctgctg acaagaagta ctcgatcggc
    10201 ctcgctattg ggactaactc tgttggctgg gccgtgatca ccgacgagta caaggtgccc
    10261 tcaaagaagt tcaaggtcct gggcaacacc gatcggcatt ccatcaagaa gaatctcatt
    10321 ggcgctctcc tgttcgacag cggcgagacg gctgaggcta cgcggctcaa gcgcaccgcc
    10381 cgcaggcggt acacgcgcag gaagaatcgc atctgctacc tgcaggagat tttctccaac
    10441 gagatggcga aggttgacga ttctttcttc cacaggctgg aggagtcatt cctcgtggag
    10501 gaggataaga agcacgagcg gcatccaatc ttcggcaaca ttgtcgacga ggttgcctac
    10561 cacgagaagt accctacgat ctaccatctg cggaagaagc tcgtggactc cacagataag
    10621 gcggacctcc gcctgatcta cctcgctctg gcccacatga ttaagttcag gggccatttc
    10681 ctgatcgagg gggatctcaa cccggacaat agcgatgttg acaagctgtt catccagctc
    10741 gtgcagacgt acaaccagct cttcgaggag aaccccatta atgcgtcagg cgtcgacgcg
    10801 aaggctatcc tgtccgctag gctctcgaag tctcggcgcc tcgagaacct gatcgcccag
    10861 ctgccgggcg agaagaagaa cggcctgttc gggaatctca ttgcgctcag cctggggctc
    10921 acgcccaact tcaagtcgaa tttcgatctc gctgaggacg ccaagctgca gctctccaag
    10981 gacacatacg acgatgacct ggataacctc ctggcccaga tcggcgatca gtacgcggac
    11041 ctgttcctcg ctgccaagaa tctgtcggac gccatcctcc tgtctgatat tctcagggtg
    11101 aacaccgaga ttacgaaggc tccgctctca gcctccatga tcaagcgcta cgacgagcac
    11161 catcaggatc tgaccctcct gaaggcgctg gtcaggcagc agctccccga gaagtacaag
    11221 gagatcttct tcgatcagtc gaagaacggc tacgctgggt acattgacgg cggggcctct
    11281 caggaggagt tctacaagtt catcaagccg attctggaga agatggacgg cacggaggag
    11341 ctgctggtga agctcaatcg cgaggacctc ctgaggaagc agcggacatt cgataacggc
    11401 agcatcccac accagattca tctcggggag ctgcacgcta tcctgaggag gcaggaggac
    11461 ttctaccctt tcctcaagga taaccgcgag aagatcgaga agattctgac tttcaggatc
    11521 ccgtactacg tcggcccact cgctaggggc aactcccgct tcgcttggat gacccgcaag
    11581 tcagaggaga cgatcacgcc gtggaacttc gaggaggtgg tcgacaaggg cgctagcgct
    11641 cagtcgttca tcgagaggat gacgaatttc gacaagaacc tgccaaatga gaaggtgctc
    11701 cctaagcact cgctcctgta cgagtacttc acagtctaca acgagctgac taaggtgaag
    11761 tatgtgaccg agggcatgag gaagccggct ttcctgtctg gggagcagaa gaaggccatc
    11821 gtggacctcc tgttcaagac caaccggaag gtcacggtta agcagctcaa ggaggactac
    11881 ttcaagaaga ttgagtgctt cgattcggtc gagatctctg gcgttgagga ccgcttcaac
    11941 gcctccctgg ggacctacca cgatctcctg aagatcatta aggataagga cttcctggac
    12001 aacgaggaga atgaggatat cctcgaggac attgtgctga cactcactct gttcgaggac
    12061 cgggagatga tcgaggagcg cctgaagact tacgcccatc tcttcgatga caaggtcatg
    12121 aagcagctca agaggaggag gtacaccggc tgggggaggc tgagcaggaa gctcatcaac
    12181 ggcattcggg acaagcagtc cgggaagacg atcctcgact tcctgaagag cgatggcttc
    12241 gcgaaccgca atttcatgca gctgattcac gatgacagcc tcacattcaa ggaggatatc
    12301 cagaaggctc aggtgagcgg ccagggggac tcgctgcacg agcatatcgc gaacctcgct
    12361 ggctcgccag ctatcaagaa ggggattctg cagaccgtga aggttgtgga cgagctggtg
    12421 aaggtcatgg gcaggcacaa gcctgagaac atcgtcattg agatggcccg ggagaatcag
    12481 accacgcaga agggccagaa gaactcacgc gagaggatga agaggatcga ggagggcatt
    12541 aaggagctgg ggtcccagat cctcaaggag cacccggtgg agaacacgca gctgcagaat
    12601 gagaagctct acctgtacta cctccagaat ggccgcgata tgtatgtgga ccaggagctg
    12661 gatattaaca ggctcagcga ttacgacgtc gatcatatcg ttccacagtc attcctgaag
    12721 gatgactcca ttgacaacaa ggtcctcacc aggtcggaca agaaccgggg caagtctgat
    12781 aatgttcctt cagaggaggt cgttaagaag atgaagaact actggcgcca gctcctgaat
    12841 gccaagctga tcacgcagcg gaagttcgat aacctcacaa aggctgagag gggcgggctc
    12901 tctgagctgg acaaggcggg cttcatcaag aggcagctgg tcgagacacg gcagatcact
    12961 aagcacgttg cgcagattct cgactcacgg atgaacacta agtacgatga gaatgacaag
    13021 ctgatccgcg aggtgaaggt catcaccctg aagtcaaagc tcgtctccga cttcaggaag
    13081 gatttccagt tctacaaggt tcgggagatc aacaattacc accatgccca tgacgcgtac
    13141 ctgaacgcgg tggtcggcac agctctgatc aagaagtacc caaagctcga gagcgagttc
    13201 gtgtacgggg actacaaggt ttacgatgtg aggaagatga tcgccaagtc ggagcaggag
    13261 attggcaagg ctaccgccaa gtacttcttc tactctaaca ttatgaattt cttcaagaca
    13321 gagatcactc tggccaatgg cgagatccgg aagcgccccc tcatcgagac gaacggcgag
    13381 acgggggaga tcgtgtggga caagggcagg gatttcgcga ccgtcaggaa ggttctctcc
    13441 atgccacaag tgaatatcgt caagaagaca gaggtccaga ctggcgggtt ctctaaggag
    13501 tcaattctgc ctaagcggaa cagcgacaag ctcatcgccc gcaagaagga ctgggatccg
    13561 aagaagtacg gcgggttcga cagccccact gtggcctact cggtcctggt tgtggcgaag
    13621 gttgagaagg gcaagtccaa gaagctcaag agcgtgaagg agctgctggg gatcacgatt
    13681 atggagcgct ccagcttcga gaagaacccg atcgatttcc tggaggcgaa gggctacaag
    13741 gaggtgaaga aggacctgat cattaagctc cccaagtact cactcttcga gctggagaac
    13801 ggcaggaagc ggatgctggc ttccgctggc gagctgcaga aggggaacga gctggctctg
    13861 ccgtccaagt atgtgaactt cctctacctg gcctcccact acgagaagct caagggcagc
    13921 cccgaggaca acgagcagaa gcagctgttc gtcgagcagc acaagcatta cctcgacgag
    13981 atcattgagc agatttccga gttctccaag cgcgtgatcc tggccgacgc gaatctggat
    14041 aaggtcctct ccgcgtacaa caagcaccgc gacaagccaa tcagggagca ggctgagaat
    14101 atcattcatc tcttcaccct gacgaacctc ggcgcccctg ctgctttcaa gtacttcgac
    14161 acaactatcg atcgcaagag gtacacaagc actaaggagg tcctggacgc gaccctcatc
    14221 caccagtcga ttaccggcct ctacgagacg cgcatcgacc tgtctcagct cgggggcgac
    14281 aagcggccag cggcgacgaa gaaggcgggg caggcgaaga agaagaaggg agacgacgga
    14341 ggtggcggta caggaggggg tgggtccgct gagtatgtca gggcgttgtt cgacttcaat
    14401 ggaaacgacg aggaagatct gccttttaaa aagggagata ttctcaggat cagagataag
    14461 ccggaagaac aatggtggaa cgctgaagac tctgaaggta agagaggtat gattcttgtc
    14521 ccctacgtcg agaagtattc gggtgactat aaagaccacg atggagatta taaggaccac
    14581 gatatagatt ataaggatga tgatgataag agcggaatga ccgatgcaga gtacgtcagg
    14641 attcatgaga aacttgacat ctacacgttt aagaaacagt ttttcaacaa caaaaaatct
    14701 gttagtcacc gctgttacgt gctgttcgaa ttgaaacgca gaggtgagag gagagcctgc
    14761 ttttggggct atgccgtcaa caagccgcaa agcggcacag aaaggggcat tcacgcggag
    14821 atatttagca ttagaaaggt cgaggaatac cttcgggata atcccgggca attcactatc
    14881 aattggtact cttcatggtc cccgtgtgca gattgcgctg aaaagatact ggagtggtat
    14941 aatcaagaac tcagaggaaa cggtcacacc ctcaagattt gggcttgcaa gctttactac
    15001 gagaaaaatg caaggaacca gatcggcctc tggaacttgc gcgacaacgg cgtggggttg
    15061 aatgtgatgg tgtcggagca ttaccagtgc tgccggaaga tattcattca gtcgtcacat
    15121 aatcaattga acgagaatag gtggctcgaa aaaaccctga agcgggccga gaagtggagg
    15181 agtgaactct cgataatgat ccaggttaaa atactgcata ctaccaaatc tccggcggtg
    15241 ggaccgaaga agaagcgcaa ggtggggacc atgactaatc tctcagatat aatcgagaag
    15301 gaaacaggaa agcaactggt catccaagaa tcgattttga tgcttcccga agaagtcgaa
    15361 gaagttatag gaaataagcc cgagtctgac atactggttc acacagcgta cgatgaaagt
    15421 acggacgaga atgtcatgtt gctgacatcg gacgcacctg aatacaagcc ttgggctctg
    15481 gtcatacaag atagtaacgg agaaaataag attaaaatgc ttgaaggaag gggctccctg
    15541 ctgacatgtg gagatgtgga agagaatcca ggaccatcca ggatgataga gcaagatggt
    15601 tgtacccaag tgctgcggcc cctcggatgg cgggggtaca gcgccatgac tggccataat
    15661 agacagtccg ctgctctcat gcctccatgc agcggatgtc agaggagggg agctaggttc
    15721 ttcctgtcta gacctacctg ccccgtgccc gagggcagag gaagtcttct aacatgcggt
    15781 gacgtggagg agaatcccgg ccctatggct cctaagaaga agcggaaggt tggtattcac
    15841 ggggtgcctg cggctatggc gtcaaatttc acgcagtttg ttttggttga taacggcggg
    15901 actggcgacg ttacagtagc tccatcaaat tttgcgaacg gagtcgctga gtggattagc
    15961 tcaaattcaa ggtcccaggc ctacaaggtt acctgttctg ttaggcagag ttctgcgcaa
    16021 aaaagaaaat ataccatcaa ggttgaagtc cctaaagttg caacacaaac agtcggtggt
    16081 gttgagctcc ctgtggcagc ctggagatct tacttaaaca tggagctaac aattccaata
    16141 ttcgctacaa actctgattg tgaactgatt gttaaggcga tgcaaggact cttgaaagat
    16201 ggaaacccta taccgtccgc tatcgcagct aacagcggta tctatggctc tggatcgggg
    16261 tcgggttctg gctcaactag ttcaggcggg tcaacaaacc tcagtgacat catagagaag
    16321 gaaactggta agcaactggt tattcaagag agcattctga tgctccctga ggaagtcgag
    16381 gaagttatag gaaacaagcc tgagagcgat atactcgtgc atacggcgta tgacgagagc
    16441 acggatgaaa atgtgatgct cttgaccagc gatgcgccag aatataaacc ctgggcactg
    16501 gttattcagg actctaacgg ggaaaataaa atcaagatgc tctcaggtgg ctccccaaag
    16561 aagaaacgca aggttggtac caagcgtcct gctgccacca aaaaggccgg acaggctaag
    16621 aaaaagaagt agtggcggcc gccgacgtcc gatcgttcaa acatttggca ataaagtttc
    16681 ttaagattga atcctgttgc cggtcttgcg atgattatca tataatttct gttgaattac
    16741 gttaagcatg taataattaa catgtaatgc atgacgttat ttatgagatg ggtttttatg
    16801 attagagtcc cgcaattata catttaatac gcgatagaaa acaaaatata gcgcgcaaac
    16861 taggataaat tatcgcgcgc ggtgtcatct atgttactag atcgggaatt gatcccccct
    16921 cgacagcttc cggaaagggc gaattcgcaa ctttgtatac aaaagttgcc ccatggcgtt
    16981 ccctctagat aacgcaggat cctatttact ttaaattttt cttatggctc agcctgtgat
    17041 ggataactga atcaaacaaa tggcgtctgg gtttaagaac atctgttttg gctatgttgg
    17101 acgaaacaag tgaactttta ggatcaactt ccgtttatat acggagctta tatcgagcaa
    17161 taagataagt gggcttttta tgtaatttaa tgggctatcg tccatatatt cactaatacc
    17221 catgcccagt acccatgtat gcgtttcata taagctccta atttctccca catcgctcaa
    17281 atctaaacaa atcttgttgt atatataaca ctgagggagc accattggtc agagaccggc
    17341 gccgctacag ggcgcgtccc attcgccatt caggctgcgc aactgttggg aagggcgatc
    17401 ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt
    17461 aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg ccagtgagcg
    17521 cgcgtaatac gactcactat agggcgaatt gggtaccggg ccccccctcg aggtcctcca
    17581 gcttttgttc cctttagtga gggttaattg cgcgcttggc gtaatcatgg tcatagctgt
    17641 ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa
    17701 agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac
    17761 tgcccgcttt ccaccggtgg tctctgtttt agagctaggc caacatgagg atcacccatg
    17821 tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg
    17881 atcacccatg tctgcagggc caagtggcac cgagtcggtg cttttttttc cctttccttt
    17941 tttctttttt ttgccataaa cttaaatttg tatatcgatc attgtagata ttgaaaacct
    18001 agaacaaacc aacatccatg tgaatgtctt tcatgactga tttagagata attcttgaat
    18061 tttggaacta gaatctataa tgagcctaaa ttaaaacatt gtgaactagt aagggcgaat
    18121 tcgacccagc tttcttgtac aaagtggttc gataattctt aattaactag ttctagagcg
    18181 gccgccaccg cggtggagct cgaatttccc cgatcgttca aacatttggc aataaagttt
    18241 cttaagattg aatcctgttg ccggtcttgc gatgattatc atataatttc tgttgaatta
    18301 cgttaagcat gtaataatta acatgtaatg catgacgtta tttatgagat gggtttttat
    18361 gattagagtc ccgcaattat acatttaata cgcgatagaa aacaaaatat agcgcgcaaa
    18421 ctaggataaa ttatcgcgcg cggtgtcatc tatgttacta gatcgggaat tcgtaatcat
    18481 gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc
    18541 cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc
    18601 gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat
    18661 cggccaacgc gcggggagag gcggtttgcg tattggctag agcagcttgc caacatggtg
    18721 gagcacgaca ctctcgtcta ctccaagaat atcaaagata cagtctcaga agaccaaagg
    18781 gctattgaga cttttcaaca aagggtaata tcgggaaacc tcctcggatt ccattgccca
    18841 gctatctgtc acttcatcaa aaggacagta gaaaaggaag gtggcaccta caaatgccat
    18901 cattgcgata aaggaaaggc tatcgttcaa gatgcctctg ccgacagtgg tcccaaagat
    18961 ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac gtcttcaaag
    19021 caagtggatt gatgtgaaca tggtggagca cgacactctc gtctactcca agaatatcaa
    19081 agatacagtc tcagaagacc aaagggctat tgagactttt caacaaaggg taatatcggg
    19141 aaacctcctc ggattccatt gcc
//
