LOCUS       sequence-76972-e         684 bp    DNA     linear   UNA 15-DEC-2025
DEFINITION  Expresses a 3x Flag TALE-TET1CD (catalytic domain of TET1) fusion 
            protein engineered to bind a site in the human beta-globin (HBB) 
            gene and demethylate CpGs adjacent to the binding site.
ACCESSION   .
VERSION     .
KEYWORDS    .
SOURCE      natural DNA sequence
  ORGANISM  unspecified
REFERENCE   1  (bases 1 to 684)
  AUTHORS   Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai 
            SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson 
            MF, Joung JK
  TITLE     Targeted DNA demethylation and activation of endogenous genes using 
            programmable TALE-TET1 fusion proteins.
  JOURNAL   Nat Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726.
  PUBMED    24108092
REFERENCE   2  (bases 1 to 684)
  AUTHORS   .
  TITLE     Direct Submission
  JOURNAL   Exported Dec 15, 2025 from SnapGene Server 8.0.1
            https://www.snapgene.com
COMMENT     SGRef: number: 1; type: "Journal Article"; journalName: "Nat 
            Biotechnol. 2013 Oct 9. doi: 10.1038/nbt.2726."
COMMENT     Sequence Label: MLM3733
FEATURES             Location/Qualifiers
     source          1..684
                     /mol_type="genomic DNA"
                     /organism="unspecified"
ORIGIN
        1 cttacagagt ttggctacac gattagctcc aatttataag cagtatgctc cagtagctta
       61 ccaaaatcag gtggaatatg aaaatgttgc ccgagaatgt cggcttggca gcaaggaagg
      121 tcgacccttc tctggggtca ctgcttgcct ggacttctgt gctcatcccc acagggacat
      181 tcacaacatg aataatggaa gcactgtggt ttgtacctta actcgagaag ataaccgctc
      241 tttgggtgtt attcctcaag atgagcagct ccatgtgcta cctctttata agctttcaga
      301 cacagatgag tttggctcca aggaaggaat ggaagccaag atcaaatctg gggccatcga
      361 ggtcctggca ccccgccgca aaaaaagaac gtgtttcact cagcctgttc cccgttctgg
      421 aaagaagagg gctgcgatga tgacagaggt tcttgcacat aagataaggg cagtggaaaa
      481 gaaacctatt ccccgaatca agcggaagaa taactcaaca acaacaaaca acagtaagcc
      541 ttcgtcactg ccaaccttag ggagtaacac tgagaccgtg caacctgaag taaaaagtga
      601 aaccgaaccc cattttatct taaaaagttc agacaacact aaaacttatt cgctgatgcc
      661 atccgctcct cacccagtga aaga
//
